General Information of Drug (ID: DMY2KX9)

Drug Name
Alendronate Drug Info
Synonyms
Arendal; Fosamax; ALENDRONATE SODIUM; ALENDRONIC ACID; Acide alendronique; Acido alendronico; Acidum alendronicum; MK 217; Acide alendronique [INN-French]; Acido alendronico [INN-Spanish]; Acidum alendronicum [INN-Latin]; Alendronic acid (INN); Alendronic acid [INN:BAN]; Bisphosphonate, 65; Fosamax (TN); MK-217; Phosphonic acid, (4-amino-1-hydroxybutylidene)bis; (4-Amino-1-hydroxybutylidene)bisphosphonic acid; (4-Amino-1-hydroxybutylidene)diphosphonic acid; (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid; (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid); 4-Amino-1-hydroxybutane-1,1-diphosphonate; 4-Amino-1-hydroxybutane-1,1-diphosphonic Acid; 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid); 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
Therapeutic ClassBone Density Conservation Agents
Cross-matching ID
PubChem CID
2088
ChEBI ID
CHEMBL870
CAS Number
CAS 66376-36-1
TTD Drug ID
D09KLR
ACDINA Drug ID
D00017

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Cardiac muscle contraction 2.20 0.00e+0 64/87 (73.56%) TNNC1;ATP2A2;TPM4;...
Thermogenesis 2.05 1.25e-2 173/232 (74.57%) PPARG;COX7B;ACTB;...
Oxidative phosphorylation 2.02 1.25e-2 93/133 (69.92%) COX7B;ATP5MC1;NDUFB5;...
Dilated cardiomyopathy 1.86 1.87e-2 86/96 (89.58%) ITGA6;ITGB4;TNNC1;...
Asthma 1.84 2.00e-2 25/31 (80.65%) HLA-DQB1;CCL11;HLA-DMB;...
Hypertrophic cardiomyopathy 1.80 3.75e-2 81/90 (90%) ITGA6;ITGB4;TNNC1;...
Diabetic cardiomyopathy 1.76 4.82e-2 162/203 (79.8%) ATP2A2;TGFBR2;COX7B;...
Nitrogen metabolism 1.72 4.99e-2 16/17 (94.12%) CA2;CA12
Primary bile acid biosynthesis -2.00 0.00e+0 15/17 (88.24%) ACOT8;AKR1D1;CYP27A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H