Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY65AR)

Drug Name
Inosine Drug Info
Synonyms
Atorel; Hypoxanthine D-riboside; Hypoxanthine nucleoside; Hypoxanthine ribonucleoside; Hypoxanthine riboside; Hypoxanthosine; INO 495; Inosie; Inosin; Inosina; Inosina [INN-Spanish]; Inosine [INN:JAN]; Inosinum; Inosinum [INN-Latin]; Oxiamin; Panholic-L; Pantholic-L; Ribonosine; Selfer; Trophicardyl; beta-Inosine; hypoxanthine-ribose; inosine; iso-prinosine; (-)-Inosine; 58-63-9; 9-beta-D-Ribofuranosylhypoxanthine; AI3-52241; Hypoxanthine, 9-beta-D-ribofuranosyl-; Hypoxanthine-9-beta-D-ribofuranoside; MFCD00066770; NSC 20262
Cross-matching ID
PubChem CID
135398641
ChEBI ID
CHEMBL1556
CAS Number
CAS 58-63-9
INTEDE Drug ID
DR2101

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.06 2.30e-2 19/20 (95%) DHCR7;SOAT1;CYP27B1;...
Pentose phosphate pathway 2.05 1.15e-2 25/30 (83.33%) PFKL;GPI;ALDOA;...
Pentose and glucuronate interconversions -1.70 4.54e-2 17/34 (50%) UGT2B17;UGT2B28;SORD;...
Linoleic acid metabolism -1.73 3.78e-2 21/29 (72.41%) PLAAT3;PLA2G10;CYP2C8;...
Pertussis -1.75 3.17e-2 64/76 (84.21%) RHOA;CASP1;ITGA5;...
Mineral absorption -1.83 1.33e-2 48/60 (80%) MT1HL1;MT1H;CYBRD1;...
Drug metabolism -2.02 1.78e-3 78/151 (51.66%) FMO5;RRM2;GMPS;...
Metabolism of xenobiotics by cytochrome P450 -2.09 2.22e-3 49/77 (63.64%) CYP3A5;UGT2B17;MGST3;...
Porphyrin and chlorophyll metabolism -2.10 0.00e+0 23/43 (53.49%) ALAS1;COX15;CPOX;...
Retinol metabolism -2.16 0.00e+0 41/68 (60.29%) CYP3A5;CYP3A7;UGT2B17;...
Complement and coagulation cascades -2.58 0.00e+0 76/85 (89.41%) CFHR4;CPB2;SERPIND1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H