Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY7PED)

• Drug Name: Cisapride Drug Info
• Synonyms: cisapride; Propulsid; Prepulsid; Syspride; Pridesia; Risamal; Acenalin; Alimix; Propulsin; Propulsid Quicksolv; Enteropride; Kinestase; 81098-60-4; Cisawal; Vomiprid; Colinorm; Cisapron; Vomipride; Unipride; Kaudalit; Alipride; Acpulsif; Rapulid; Cipride; Pulsid; Esorid; Dispep; Presid; Unamol; Guptro; Alimix Forte; Cisapridum [Latin]; Cisaprida [Spanish]; R-51619; Cisapridum [INN-Latin]; R 51619; Cisaprida [INN-Spanish]; 104860-73-3; DCSUBABJRXZOMT-UHFFFAOYSA-N; T 1341; DSSTox_CID_2825; Acenalin; Cisaprida; Cisapridum; Risamol; Prepulsid (TN); Propulsid (TN); Cisapride (USAN/INN); Cisapride [USAN:BAN:INN:JAN]; Cis-4-Amino-5-chloro-N-(1-(3-(p-fluorophenoxy)propyl)-3-methoxy-4-piperidyl)-o-anisamide; (+-)-Cisapride; 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide; 4-amino-5-chloro-N-[1-{3-[(4-fluorophenyl)oxy]propyl}-3-(methyloxy)piperidin-4-yl]-2-(methyloxy)benzamide; 4-amino-5-chloro-N-{1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-yl}-2-methoxybenzamide; E-1454
• Therapeutic Class: Gastrointestinal Agents
• Cross-matching ID:
  PubChem CID: 6917698
  ChEBI ID: CHEMBL560739
  CAS Number: CAS 81098-60-4
  TTD Drug ID: D0BD8D
  VARIDT Drug ID: DR00794
  INTEDE Drug ID: DR0331

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	2.04	0.00e+0	110/124 (88.71%)	CDC20;CDC25B;MCM6;...
DNA replication	1.99	5.00e-3	34/36 (94.44%)	MCM6;MCM3;MCM2;...
mRNA surveillance pathway	1.89	1.33e-2	71/98 (72.45%)	FUS;RNPS1;PCF11;...
Oocyte meiosis	1.88	1.00e-2	90/129 (69.77%)	CDC20;AR;ADCY7;...
RNA transport	1.84	1.60e-2	128/186 (68.82%)	FUS;KPNB1;RNPS1;...
Ribosome biogenesis in eukaryotes	1.70	4.62e-2	52/108 (48.15%)	NOP56;DROSHA;NXF3;...
Lipid and atherosclerosis	-1.61	4.52e-2	190/215 (88.37%)	CASP1;LYN;PTK2;...
Ovarian steroidogenesis	-1.62	4.50e-2	41/51 (80.39%)	PRKACA;CYP1A1;HSD3B2;...
NF-kappa B signaling pathway	-1.63	4.12e-2	90/104 (86.54%)	CSNK2A2;CD40;CHUK;...
Pertussis	-1.64	4.13e-2	64/76 (84.21%)	C4BPA;FOS;C3;...
Protein export	-1.64	4.26e-2	17/23 (73.91%)	SRP72;HSPA5;SRP54;...
Vasopressin-regulated water reabsorption	-1.64	4.46e-2	40/44 (90.91%)	NSF;DYNLL1;ARHGDIB;...
Complement and coagulation cascades	-1.65	4.10e-2	76/85 (89.41%)	F2R;F8;C6;...
Pyruvate metabolism	-1.66	4.10e-2	41/47 (87.23%)	ADH1C;PDHB;ACAT1;...
Renin secretion	-1.66	4.05e-2	61/69 (88.41%)	PRKACA;REN;AGTR1;...
Synaptic vesicle cycle	-1.67	3.56e-2	63/78 (80.77%)	ATP6V0A1;SLC1A2;SLC6A5;...
Mitophagy	-1.68	3.41e-2	56/68 (82.35%)	CSNK2A2;MRAS;MITF;...
Tyrosine metabolism	-1.68	3.63e-2	30/36 (83.33%)	DBH;GOT2;TH;...
Prion disease	-1.72	3.13e-2	209/273 (76.56%)	CACNA1D;KIF5B;NDUFB1;...
Huntington disease	-1.72	2.86e-2	233/306 (76.14%)	NDUFAB1;NDUFS3;PSMC2;...
Staphylococcus aureus infection	-1.73	2.69e-2	72/95 (75.79%)	HLA-DQA1;SELP;PTAFR;...
IL-17 signaling pathway	-1.73	2.92e-2	84/94 (89.36%)	CHUK;IL17RB;FOS;...
Metabolism of xenobiotics by cytochrome P450	-1.76	2.18e-2	49/77 (63.64%)	GSTM4;GSTM5;CBR1;...
Phagosome	-1.78	2.20e-2	118/152 (77.63%)	SEC61A1;ATP6V1C1;HLA-A;...
Collecting duct acid secretion	-1.82	1.56e-2	22/27 (81.48%)	SLC4A1;ATP6V0A1;ATP6V1C1;...
Arachidonic acid metabolism	-1.84	1.25e-2	48/61 (78.69%)	PLAAT3;PLA2G5;GGT5;...
Legionellosis	-1.86	1.14e-2	51/57 (89.47%)	HSPA2;C3;CASP3;...
Steroid hormone biosynthesis	-1.88	8.34e-3	43/61 (70.49%)	CYP2E1;HSD11B1;CYP1A1;...
Rheumatoid arthritis	-1.91	4.00e-3	78/93 (83.87%)	CD86;ATP6V1E1;TCIRG1;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.97	0.00e+0	62/70 (88.57%)	ATP6V1E1;ADAM10;TCIRG1;...
Vibrio cholerae infection	-2.01	0.00e+0	44/50 (88%)	SEC61A1;ATP6V1C1;ATP6V1E1;...
Parkinson disease	-2.24	0.00e+0	176/249 (70.68%)	NDUFAB1;NDUFS3;PSMC2;...
Oxidative phosphorylation	-2.29	0.00e+0	93/133 (69.92%)	NDUFB1;NDUFS7;ATP6V0A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼