Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY85QW)

Drug Name
Bazedoxifene Drug Info
Synonyms Brilence; Conbriza; Viviant; Bazedoxifene acetate; TSE-424; WAY-140424; WAY-TES 424
Cross-matching ID
PubChem CID
154257
ChEBI ID
CHEMBL46740
CAS Number
CAS 198481-32-2
TTD Drug ID
D0JY8T
INTEDE Drug ID
DR0177

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.22 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
Epithelial cell signaling in Helicobacter pylori infect... 2.18 0.00e+0 62/70 (88.57%) CXCL2;CXCL3;ATP6V0E1;...
Lysosome 2.13 4.10e-3 115/128 (89.84%) CTSS;CTSB;GLB1;...
IL-17 signaling pathway 2.09 3.08e-3 84/94 (89.36%) CXCL2;LCN2;S100A9;...
Terpenoid backbone biosynthesis 2.06 2.46e-3 18/22 (81.82%) HMGCR;ACAT2;PCYOX1;...
Rheumatoid arthritis 2.01 4.10e-3 78/93 (83.87%) CXCL2;CXCL3;ATP6V0E1;...
TNF signaling pathway 1.98 3.52e-3 103/112 (91.96%) CXCL2;CASP10;CXCL3;...
Complement and coagulation cascades 1.95 4.62e-3 76/85 (89.41%) CLU;CFI;F2R;...
Leukocyte transendothelial migration 1.95 4.10e-3 90/114 (78.95%) PIK3R1;MMP9;ITGAM;...
Fc gamma R-mediated phagocytosis 1.93 3.69e-3 79/97 (81.44%) PIK3R1;PLPP3;MARCKSL1;...
Synthesis and degradation of ketone bodies 1.91 3.36e-3 9/10 (90%) ACAT2;BDH2;HMGCS1;...
Leishmaniasis 1.87 4.10e-3 67/77 (87.01%) ITGAM;MARCKSL1;CYBB;...
Neutrophil extracellular trap formation 1.85 4.73e-3 101/189 (53.44%) PLCB1;AQP9;PIK3R1;...
NOD-like receptor signaling pathway 1.83 8.79e-3 145/181 (80.11%) CXCL2;PLCB1;CXCL3;...
Lipid and atherosclerosis 1.80 1.07e-2 190/215 (88.37%) CXCL2;TNFSF10;PLCB1;...
Carbohydrate digestion and absorption 1.80 1.00e-2 37/47 (78.72%) PLCB1;PIK3R1;SLC37A4;...
Butanoate metabolism 1.77 1.16e-2 23/28 (82.14%) ACAT2;ACSM3;BDH2;...
NF-kappa B signaling pathway 1.75 1.64e-2 90/104 (86.54%) CXCL2;IL1R1;CXCL3;...
Synaptic vesicle cycle 1.75 1.62e-2 63/78 (80.77%) ATP6V0E1;SYT1;SNAP25;...
Collecting duct acid secretion 1.74 1.54e-2 22/27 (81.48%) ATP6V0E1;ATP6V1B2;ATP6V1A;...
Osteoclast differentiation 1.73 1.76e-2 117/127 (92.13%) IL1R1;PIK3R1;BLNK;...
Peroxisome 1.71 2.41e-2 72/82 (87.8%) IDH1;AMACR;FAR2;...
Chemokine signaling pathway 1.71 2.35e-2 163/192 (84.9%) CXCL2;PLCB1;CXCL3;...
B cell receptor signaling pathway 1.70 2.56e-2 71/81 (87.65%) IFITM1;PIK3R1;BLNK;...
Glycolysis / Gluconeogenesis 1.70 2.46e-2 56/67 (83.58%) ADH5;PKM;ALDH2;...
Other glycan degradation 1.69 2.65e-2 13/18 (72.22%) GLB1;HEXB;NEU1;...
Vibrio cholerae infection 1.69 2.55e-2 44/50 (88%) ATP6V0E1;SLC12A2;ATP6V1B2;...
Legionellosis 1.68 2.68e-2 51/57 (89.47%) CXCL2;CXCL3;ITGAM;...
Mucin type O-glycan biosynthesis 1.67 2.84e-2 20/36 (55.56%) GALNT1;GALNT6;ST6GALNAC2;...
Autophagy 1.67 2.95e-2 113/169 (66.86%) DAPK1;CTSB;PIK3R1;...
Autoimmune thyroid disease -1.65 2.55e-2 46/53 (86.79%) HLA-DQA1;TSHR;PRF1;...
Base excision repair -1.66 2.30e-2 29/33 (87.88%) NEIL3;PARP1;POLE;...
Homologous recombination -1.70 1.42e-2 35/41 (85.37%) RPA1;RAD51;RBBP8;...
Allograft rejection -1.78 6.20e-3 32/38 (84.21%) HLA-DQA1;IFNG;PRF1;...
ECM-receptor interaction -1.82 4.11e-3 80/88 (90.91%) LAMB3;ITGA10;CHAD;...
Nucleotide excision repair -1.82 4.45e-3 40/47 (85.11%) RFC2;XPA;RPA1;...
p53 signaling pathway -1.83 4.25e-3 63/73 (86.3%) PMAIP1;CCNB1;FAS;...
Protein digestion and absorption -1.87 2.00e-3 78/103 (75.73%) COL5A3;COL21A1;CTRL;...
Cell cycle -1.90 1.48e-3 110/124 (88.71%) CDC27;CHEK1;ORC4;...
Spliceosome -2.01 0.00e+0 101/150 (67.33%) PRPF38B;SNU13;SNRNP40;...
RNA polymerase -2.01 0.00e+0 23/31 (74.19%) POLR2E;POLR3G;POLR3F;...
Mismatch repair -2.06 0.00e+0 22/23 (95.65%) PCNA;SSBP1;MLH1;...
Fanconi anemia pathway -2.07 0.00e+0 36/54 (66.67%) RPA1;RAD51;REV1;...
Ribosome -2.17 0.00e+0 113/158 (71.52%) RPS7;RPL31;RPL22;...
RNA transport -2.28 0.00e+0 128/186 (68.82%) EIF3F;NUP58;NUP37;...
DNA replication -2.29 0.00e+0 34/36 (94.44%) RNASEH1;RPA1;POLE;...
Ribosome biogenesis in eukaryotes -2.46 0.00e+0 52/108 (48.15%) FCF1;CSNK2A2;EIF6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.04uM - 10uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H