Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY8NC4)

Drug Name
Cefoxitin Drug Info
Synonyms
Cefoxitina; Cefoxitine; Cefoxitinum; Cefoxotin; Cenomycin; Mefoxin; Mefoxitin; Rephoxitin; cefoxitin; ceftoxitin; 35607-66-0; CEPHOXITIN; 4kow; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-, (6R,7S)-; 6OEV9DX57Y; AK118716; CAS-35607-66-0; CFX; CHEBI:209807; CHEMBL996; DSSTox_CID_2764; DSSTox_GSID_22764; DSSTox_RID_76721; NCGC00183034-01; UNII-6OEV9DX57Y
Cross-matching ID
PubChem CID
441199
ChEBI ID
CHEMBL996
CAS Number
CAS 35607-66-0
TTD Drug ID
D02VFC
INTEDE Drug ID
DR2492

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Progesterone-mediated oocyte maturation 1.87 1.90e-2 75/100 (75%) STK10;PLK1;CCNB2;...
Hematopoietic cell lineage 1.87 1.43e-2 90/99 (90.91%) IL7R;IL6R;HLA-DQB1;...
ECM-receptor interaction 1.81 3.17e-2 80/88 (90.91%) VWF;TNC;COL2A1;...
Caffeine metabolism -1.68 4.94e-2 5/6 (83.33%) NAT2;CYP1A2
Sulfur metabolism -1.73 2.16e-2 9/10 (90%) MPST;SQOR;PAPSS2;...
Thiamine metabolism -1.74 2.26e-2 12/15 (80%) AK2;TPK1;AK1;...
Drug metabolism -1.81 8.29e-3 78/151 (51.66%) UGT2B28;ADH7;GSTA1;...
Protein processing in endoplasmic reticulum -1.81 9.21e-3 127/171 (74.27%) SSR1;SEC24D;SAR1B;...
Linoleic acid metabolism -1.89 5.18e-3 21/29 (72.41%) CYP2J2;CYP3A4;CYP2C8;...
Nitrogen metabolism -1.91 1.48e-3 16/17 (94.12%) GLUL;GLUD2;CPS1;...
Retinol metabolism -1.91 1.73e-3 41/68 (60.29%) CYP2W1;RDH16;UGT2B17;...
Folate biosynthesis -1.93 2.07e-3 23/26 (88.46%) ALPL;MOCS2;CBR1;...
Metabolism of xenobiotics by cytochrome P450 -2.00 2.59e-3 49/77 (63.64%) ADH6;GSTO1;ALDH3B1;...
Steroid hormone biosynthesis -2.02 3.45e-3 43/61 (70.49%) UGT2B17;STS;AKR1C4;...
Arachidonic acid metabolism -2.04 5.18e-3 48/61 (78.69%) CYP2C8;PLA2G10;GPX2;...
Mineral absorption -2.20 0.00e+0 48/60 (80%) CYBRD1;ATP2B1;SLC39A4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H