Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMY8RT9)

Drug Name
NCGC00167772-01 Drug Info
Synonyms 10-DEBC
Cross-matching ID
PubChem CID
10521421
ChEBI ID
CHEMBL1398474
TTD Drug ID
D0Q1HF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.52 0.00e+0 19/20 (95%) MSMO1;SQLE;DHCR7;...
Terpenoid backbone biosynthesis 2.09 5.86e-3 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Pyrimidine metabolism 1.98 3.90e-3 40/56 (71.43%) UPP1;DCK;PNP;...
Biosynthesis of unsaturated fatty acids 1.88 2.05e-2 21/27 (77.78%) SCD;FADS2;FADS1;...
VEGF signaling pathway 1.84 2.34e-2 50/59 (84.75%) SPHK1;PRKCA;CDC42;...
Synthesis and degradation of ketone bodies 1.81 2.54e-2 9/10 (90%) HMGCS1;ACAT2
Synaptic vesicle cycle 1.80 2.68e-2 63/78 (80.77%) TCIRG1;SLC1A1;STX3;...
Mucin type O-glycan biosynthesis 1.75 4.10e-2 20/36 (55.56%) GALNT3;GALNT6;GALNT1;...
Complement and coagulation cascades 1.74 3.90e-2 76/85 (89.41%) TFPI;SERPINB2;F12;...
Rheumatoid arthritis 1.74 3.86e-2 78/93 (83.87%) TGFB1;CXCL2;TCIRG1;...
DNA replication 1.73 3.94e-2 34/36 (94.44%) POLE2;MCM2;PCNA;...
Malaria 1.71 4.59e-2 44/50 (88%) THBS2;TGFB1;SDC1;...
Viral protein interaction with cytokine and cytokine re... 1.71 4.59e-2 84/100 (84%) PPBP;CXCL2;CXCL12;...
Pyruvate metabolism 1.70 4.68e-2 41/47 (87.23%) ACAT2;PKM;ADH1B;...
Vibrio cholerae infection 1.68 4.90e-2 44/50 (88%) GNAS;KDELR3;PRKCA;...
Amino sugar and nucleotide sugar metabolism 1.67 4.82e-2 38/48 (79.17%) PMM2;GNPDA1;GALE;...
Glycolysis / Gluconeogenesis 1.67 4.68e-2 56/67 (83.58%) PKM;ENO2;ALDOC;...
Thyroid cancer -1.85 1.33e-2 36/37 (97.3%) CCDC6;RXRB;TPR;...
Basal cell carcinoma -2.10 0.00e+0 41/63 (65.08%) GADD45G;FZD10;WNT5A;...
Spliceosome -2.20 0.00e+0 101/150 (67.33%) PRPF38B;SNRPC;LSM6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 25uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 25uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 25uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 25uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 25uM 6H
MDST8 CVCL_1400 Homo sapiens 25uM 6H
NCI-H508 CVCL_1561 Homo sapiens 25uM 6H
SNU-1040 CVCL_5001 Homo sapiens 25uM 6H
SNU-C4 CVCL_5008 Homo sapiens 25uM 6H
SNU-C5 CVCL_5009 Homo sapiens 25uM 6H
SW480 CVCL_0546 Homo sapiens 25uM 6H
SW620 CVCL_0547 Homo sapiens 25uM 6H
SW948 CVCL_0550 Homo sapiens 25uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 25uM 6H
HT115 CVCL_1294 Homo sapiens 25uM 6H
RKO CVCL_0504 Homo sapiens 25uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 25uM 6H
SNG-M CVCL_1707 Homo sapiens 25uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 25uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 25uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 25uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 25uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 25uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 25uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 25uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 25uM 6H
T3M-10 CVCL_1729 Homo sapiens 25uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 25uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 25uM 6H
HCC515 CVCL_5134 Homo sapiens 25uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 25uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 25uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 25uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 25uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 25uM 6H
OV7 CVCL_1623 Homo sapiens 25uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 25uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 25uM 6H
RMUG-S CVCL_1666 Homo sapiens 25uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 25uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 25uM 6H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 25uM 6H
PL-21 CVCL_2161 Homo sapiens 25uM 6H
SKM-1 CVCL_0010 Homo sapiens 25uM 6H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 25uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 25uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 25uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 25uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 25uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 25uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 25uM 6H