Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYAA80)

Drug Name
Nefopam Drug Info
Synonyms
Nefopam hydrochloride; 23327-57-3; Nefopam HCl; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride; Acupan; Nefopam (hydrochloride); Ajan; Pallopikeron; Leoplexamin; Lenipan; Sinalgico; Oxadol; Fenazoxine hydrochloride; Nefopam hydrochloride [USAN]; EINECS 245-585-5; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride; DSSTox_CID_25441; DSSTox_RID_80882; DSSTox_GSID_45441; 69319-31-9; Nefopam hydrochloride (USAN); R 738; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine
Cross-matching ID
PubChem CID
4450
ChEBI ID
CHEMBL465026
CAS Number
CAS 13669-70-0
TTD Drug ID
D05AFX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.95 2.38e-2 34/36 (94.44%) POLE2;RFC3;RFC5;...
Pentose and glucuronate interconversions 1.87 1.58e-2 17/34 (50%) AKR1B10;SORD;UGT2A3;...
Metabolism of xenobiotics by cytochrome P450 1.85 1.32e-2 49/77 (63.64%) AKR7A2;ADH1C;CYP3A5;...
Retinol metabolism 1.83 1.78e-2 41/68 (60.29%) DHRS9;ADH1C;CYP3A5;...
Cell cycle 1.81 1.90e-2 110/124 (88.71%) PLK1;E2F2;BUB1;...
Folate biosynthesis 1.77 2.51e-2 23/26 (88.46%) GGH;AKR1C3;AKR1B10;...
Mismatch repair 1.75 2.38e-2 22/23 (95.65%) RFC3;RFC5;PCNA;...
Drug metabolism 1.74 2.67e-2 78/151 (51.66%) RRM2;NAT1;ADH1C;...
Butanoate metabolism 1.74 2.46e-2 23/28 (82.14%) HMGCS2;ALDH5A1;HADH;...
Terpenoid backbone biosynthesis 1.71 3.01e-2 18/22 (81.82%) HMGCS2;ICMT;IDI1;...
Homologous recombination 1.70 3.67e-2 35/41 (85.37%) RBBP8;BLM;BARD1;...
Propanoate metabolism 1.69 3.63e-2 30/34 (88.24%) DLD;SUCLG2;SUCLA2;...
Asthma -1.84 4.41e-2 25/31 (80.65%) PRG2;HLA-DPB1;HLA-DQA1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H