Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYBQM7)

Drug Name
PNU-120596 Drug Info
Synonyms PNU-120,596
Cross-matching ID
PubChem CID
311434
ChEBI ID
CHEMBL257591
CAS Number
CAS 501925-31-1
TTD Drug ID
D03FPQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.38 0.00e+0 34/36 (94.44%) POLE2;MCM4;POLD2;...
Complement and coagulation cascades 2.14 0.00e+0 76/85 (89.41%) SERPINA1;C4BPA;PLAT;...
ECM-receptor interaction 2.01 3.46e-3 80/88 (90.91%) CD36;TNC;THBS1;...
Cholesterol metabolism 1.88 1.56e-2 44/50 (88%) CD36;LPL;TSPO;...
Axon guidance 1.87 1.24e-2 151/182 (82.97%) EPHA3;GNAI1;NFATC3;...
Neutrophil extracellular trap formation 1.86 1.04e-2 101/189 (53.44%) AZU1;PRKCA;CTSG;...
Homologous recombination 1.84 1.18e-2 35/41 (85.37%) POLD2;RPA3;BARD1;...
Nucleotide excision repair 1.83 1.17e-2 40/47 (85.11%) POLE2;POLD2;GTF2H3;...
Amino sugar and nucleotide sugar metabolism -1.86 2.89e-2 38/48 (79.17%) GMDS;RENBP;HEXB;...
IL-17 signaling pathway -1.89 3.38e-2 84/94 (89.36%) HSP90B1;FOS;IL6;...
Collecting duct acid secretion -2.14 9.65e-3 22/27 (81.48%) TCIRG1;ATP6V0A4;ATP6V1G1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H