Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYC2LE)

Drug Name
Disufenton Drug Info
Synonyms
168021-77-0; UNII-797K01YF1M; 797K01YF1M; N-tert-butyl-1-(2,4-disulfophenyl)methanimine oxide; SCHEMBL727315; CHEMBL2111090; 2,4-disulfophenyl-N-t-butylnitrone; alpha-(2,4-disulfophenyl)-N-tert-butylnitrone; Q27266726
Cross-matching ID
PubChem CID
151179
CAS Number
CAS 168021-77-0
TTD Drug ID
D7M3JN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.13 0.00e+0 44/46 (95.65%) PSMC3;PSMA7;PSMB1;...
Protein digestion and absorption 1.95 6.29e-3 78/103 (75.73%) COL3A1;COL4A6;MEP1A;...
Cell cycle 1.94 4.19e-3 110/124 (88.71%) CDC20;PLK1;TGFB1;...
Steroid biosynthesis 1.88 1.57e-2 19/20 (95%) DHCR24;SQLE;DHCR7;...
Spliceosome 1.80 2.77e-2 101/150 (67.33%) HSPA8;SNRPG;PUF60;...
Oocyte meiosis 1.77 2.94e-2 90/129 (69.77%) CDC20;PPP3CA;PLK1;...
ECM-receptor interaction 1.77 2.52e-2 80/88 (90.91%) ITGA6;SDC1;COL4A6;...
DNA replication 1.75 2.36e-2 34/36 (94.44%) MCM2;MCM7;MCM5;...
Toxoplasmosis 1.73 4.33e-2 103/112 (91.96%) HSPA8;TLR4;CD40;...
IL-17 signaling pathway -1.75 3.33e-2 84/94 (89.36%) S100A8;IL1B;TRAF3IP2;...
Epithelial cell signaling in Helicobacter pylori infect... -1.77 2.96e-2 62/70 (88.57%) ATP6V1H;ATP6V0A2;MAP2K4;...
Collecting duct acid secretion -1.84 1.85e-2 22/27 (81.48%) SLC12A7;ATP6V1A;ATP6V1B2;...
Complement and coagulation cascades -2.41 0.00e+0 76/85 (89.41%) PLG;F10;C1S;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H