Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYC51H)

• Drug Name: PD 128907 Drug Info
• Synonyms: (4As,10bS)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol; PBPO; PBTO; PD128907; PD-128907; CHEMBL97424; [3H]PD 128907; 123594-64-9; (4aS,10bS)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol; trans-(+-)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol; 3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol; 2H,5H-(1)Benzopyrano(4,3-b)-1,4-oxazin-9-ol, 3,4,4a,10b-tetrahydro-4-propyl-, (4aR,10bR)-rel-; 2H,5H-(1)Benzopyrano(4,3-b)-1,4-oxazin-9-ol, 3,4,4a,10b-tetrahydro-4-propyl-, trans-(+-)-; PD-128,907; PD128907; [3H]PD128907
• Cross-matching ID:
  PubChem CID: 115107
  ChEBI ID: CHEMBL97424
  CAS Number: CAS 123594-64-9
  TTD Drug ID: D00CDM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Citrate cycle (TCA cycle)	2.20	0.00e+0	30/30 (100%)	SDHB;ACLY;DLD;...
Viral protein interaction with cytokine and cytokine re...	-1.79	1.57e-2	84/100 (84%)	CCL21;IL37;CCL4;...
Protein processing in endoplasmic reticulum	-1.82	1.37e-2	127/171 (74.27%)	RNF5;ERP29;STT3A;...
NF-kappa B signaling pathway	-1.90	8.57e-3	90/104 (86.54%)	ERC1;TNF;MALT1;...
Nicotinate and nicotinamide metabolism	-1.97	2.86e-3	25/35 (71.43%)	QPRT;NMRK2;SIRT5;...
IL-17 signaling pathway	-1.98	4.28e-3	84/94 (89.36%)	IL6;MMP13;MUC5AC;...
Legionellosis	-2.29	0.00e+0	51/57 (89.47%)	HBS1L;IL6;ITGAM;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲