Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYFRTB)

Drug Name
PCM-075 Drug Info
Synonyms Onvansertib
Cross-matching ID
PubChem CID
49792852
ChEBI ID
CHEMBL1738758
CAS Number
CAS 1034616-18-6
TTD Drug ID
D03HUX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome biogenesis in eukaryotes 2.13 0.00e+0 52/108 (48.15%) RPP38;PWP2;GAR1;...
Proteasome 2.06 0.00e+0 44/46 (95.65%) PSMD12;PSME4;PSMC5;...
Mineral absorption 1.78 3.94e-2 48/60 (80%) MT1E;MT1H;MT1G;...
Citrate cycle (TCA cycle) -1.67 3.63e-2 30/30 (100%) PDHA1;ACO2;SUCLA2;...
Peroxisome -1.69 3.40e-2 72/82 (87.8%) ACOX2;PEX11A;PXMP4;...
Nitrogen metabolism -1.69 3.62e-2 16/17 (94.12%) CA14;CPS1;CA4;...
Pyruvate metabolism -1.69 3.67e-2 41/47 (87.23%) ALDH9A1;PDHB;DLD;...
Tyrosine metabolism -1.73 2.60e-2 30/36 (83.33%) ADH6;ADH1A;TH;...
Glutathione metabolism -1.77 1.58e-2 43/57 (75.44%) OPLAH;GPX2;GSTA3;...
Steroid biosynthesis -1.78 1.56e-2 19/20 (95%) HSD17B7;DHCR7;LIPA;...
Pentose and glucuronate interconversions -1.83 1.27e-2 17/34 (50%) AKR1B1;UGT2B15;UGT2B4;...
Steroid hormone biosynthesis -1.85 1.12e-2 43/61 (70.49%) SULT1E1;HSD17B12;CYP19A1;...
Oxidative phosphorylation -1.85 1.24e-2 93/133 (69.92%) SDHC;ATP5F1A;ATP5F1D;...
Ascorbate and aldarate metabolism -1.86 1.28e-2 15/30 (50%) UGT2B15;UGT2B4;KL;...
Fatty acid degradation -1.90 8.00e-3 40/43 (93.02%) ACADSB;ACADVL;ADH6;...
Glyoxylate and dicarboxylate metabolism -1.93 4.67e-3 23/30 (76.67%) CS;GLDC;GRHPR;...
Proximal tubule bicarbonate reclamation -1.97 1.87e-3 21/23 (91.3%) AQP1;ATP1B2;CA4;...
Mismatch repair -1.98 2.33e-3 22/23 (95.65%) RFC3;MSH3;MLH1;...
Drug metabolism -2.03 0.00e+0 78/151 (51.66%) CYP2E1;MAOB;ADH5;...
Metabolism of xenobiotics by cytochrome P450 -2.23 0.00e+0 49/77 (63.64%) MGST2;CYP2F1;ADH6;...
DNA replication -2.25 0.00e+0 34/36 (94.44%) LIG1;RNASEH2A;RFC4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H