Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYGHX5)

Drug Name
Moxidectin Drug Info
Synonyms
Moxidectin; ProHeart 6; UNII-NGU5H31YO9; Cydectin; NGU5H31YO9; Moxidectine [INN-French]; Moxidectinum [INN-Latin]; Moxidectina [INN-Spanish]; C37H53NO8; Moxidectina; Moxidectine; Moxidectinum; Moxidectin [USAN:INN:BAN]
Cross-matching ID
PubChem CID
9832912
CAS Number
CAS 113507-06-5
TTD Drug ID
D05AWP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Cardiac muscle contraction 1.97 0.00e+0 64/87 (73.56%) COX4I1;CACNA2D3;COX5B;...
Homologous recombination 1.82 5.00e-2 35/41 (85.37%) BARD1;RAD51;RPA3;...
One carbon pool by folate 1.82 3.33e-2 15/20 (75%) MTR;ATIC;MTHFD1;...
Phenylalanine metabolism 1.71 4.74e-2 14/17 (82.35%) PAH;MAOB;GLYAT;...
DNA replication 1.65 5.00e-2 34/36 (94.44%) RPA3;RFC5;POLD3;...
Propanoate metabolism 1.65 4.61e-2 30/34 (88.24%) ACAT2;ACOX1;ECHS1;...
Ferroptosis -1.67 3.82e-2 36/41 (87.8%) PCBP2;STEAP3;GCLM;...
Th1 and Th2 cell differentiation -1.68 3.58e-2 80/92 (86.96%) HLA-DRA;RUNX3;IFNG;...
Viral myocarditis -1.71 2.99e-2 53/60 (88.33%) HLA-DOB;HLA-B;CASP8;...
Toxoplasmosis -1.72 2.54e-2 103/112 (91.96%) CASP8;HLA-DOA;TGFB2;...
Tuberculosis -1.72 2.69e-2 159/180 (88.33%) CASP8;ITGAX;HLA-DOA;...
Intestinal immune network for IgA production -1.72 2.78e-2 38/48 (79.17%) CCL25;IL15RA;HLA-DPA1;...
Inflammatory bowel disease -1.74 2.63e-2 58/65 (89.23%) IL10;IL12RB1;STAT4;...
Amino sugar and nucleotide sugar metabolism -1.81 1.32e-2 38/48 (79.17%) CYB5R1;FPGT;UGP2;...
Complement and coagulation cascades -1.84 8.55e-3 76/85 (89.41%) F9;FGG;PROC;...
Allograft rejection -1.90 3.09e-3 32/38 (84.21%) TNF;IL5;HLA-DOB;...
Type I diabetes mellitus -1.92 2.24e-3 38/43 (88.37%) TNF;GAD1;HLA-DOB;...
Autoimmune thyroid disease -1.92 2.47e-3 46/53 (86.79%) HLA-DPA1;HLA-DRB1;PRF1;...
Antigen processing and presentation -1.97 1.37e-3 60/78 (76.92%) HLA-DOB;HLA-B;HLA-DOA;...
Systemic lupus erythematosus -2.01 0.00e+0 45/135 (33.33%) C8G;FCGR3B;HLA-DRA;...
Graft-versus-host disease -2.01 0.00e+0 32/42 (76.19%) HLA-DOB;HLA-B;HLA-DOA;...
Asthma -2.02 0.00e+0 25/31 (80.65%) IL10;TNF;IL5;...
Notch signaling pathway -2.03 0.00e+0 49/59 (83.05%) DTX2;HDAC1;TLE1;...
Phagosome -2.04 0.00e+0 118/152 (77.63%) DYNC1LI1;HLA-B;COLEC12;...
Leishmaniasis -2.04 0.00e+0 67/77 (87.01%) FCGR3B;HLA-DRA;IFNG;...
Toll-like receptor signaling pathway -2.05 0.00e+0 94/104 (90.38%) TLR6;MAPK9;RIPK1;...
Staphylococcus aureus infection -2.19 0.00e+0 72/95 (75.79%) FCGR3B;KRT24;HLA-DRA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H