Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYHR74)

• Drug Name: CP154,526 Drug Info
• Synonyms: CP-154526; 157286-86-7; CP 154,526; CHEMBL9946; CP154526; UNII-9A549FB00R; 9A549FB00R; CHEMBL475903; CP-154526-1; CP-154,526; N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine; N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo(2,3-d)pyrimidin-4-amine; PDSP1_001299; AC1NSJWW; CP154,526; butyl-(2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)ethylamine; SCHEMBL5707848; GTPL3495; FHQYJZCJRZHINA-UHFFFAOYSA-N; ZINC1539133; BCP26372; BDBM50058163; BDBM50369802
• Cross-matching ID:
  PubChem CID: 5311055
  ChEBI ID: CHEMBL9946
  CAS Number: CAS 157286-86-7
  TTD Drug ID: D02IOC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
NF-kappa B signaling pathway	2.06	0.00e+0	90/104 (86.54%)	CXCL2;CXCL3;CXCL8;...
TNF signaling pathway	2.00	0.00e+0	103/112 (91.96%)	CXCL2;CXCL3;PTGS2;...
IL-17 signaling pathway	1.82	3.14e-2	84/94 (89.36%)	CXCL2;CXCL3;CXCL8;...
Cytokine-cytokine receptor interaction	1.79	3.93e-2	246/295 (83.39%)	CXCL2;CXCL3;CXCL8;...
Asthma	1.76	4.61e-2	25/31 (80.65%)	PRG2;CD40;HLA-DQA1;...
p53 signaling pathway	-2.01	0.00e+0	63/73 (86.3%)	CCNG2;CASP9;BBC3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Hide ▲