Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYHWS1)

Drug Name
WHI-P154 Drug Info
Cross-matching ID
PubChem CID
3795
ChEBI ID
CHEMBL473773
CAS Number
CAS 211555-04-3
TTD Drug ID
D0E5IP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Metabolism of xenobiotics by cytochrome P450 2.08 9.05e-3 49/77 (63.64%) ALDH3A1;CYP1B1;ADH1C;...
Steroid hormone biosynthesis 1.98 1.81e-2 43/61 (70.49%) AKR1C3;CYP1B1;HSD17B8;...
Selenocompound metabolism 1.93 1.21e-2 11/17 (64.71%) TXNRD1;CTH;PAPSS2;...
Sulfur metabolism 1.91 9.05e-3 9/10 (90%) SELENBP1;TST;ETHE1;...
Alanine, aspartate and glutamate metabolism 1.86 1.27e-2 27/37 (72.97%) ASNS;GLUL;ASS1;...
Ferroptosis 1.77 3.32e-2 36/41 (87.8%) SLC7A11;FTH1;SLC3A2;...
Glycine, serine and threonine metabolism 1.76 2.84e-2 31/40 (77.5%) PHGDH;PSAT1;SHMT2;...
Pentose and glucuronate interconversions 1.76 2.60e-2 17/34 (50%) CRYL1;AKR1B10;UGT2B15;...
Primary bile acid biosynthesis 1.75 2.41e-2 15/17 (88.24%) HSD17B4;AMACR;AKR1C4;...
Tryptophan metabolism 1.70 4.34e-2 35/42 (83.33%) IDO1;KYNU;CYP1B1;...
Ribosome 1.70 4.20e-2 113/158 (71.52%) RSL24D1;RPL10A;MRPS16;...
Phagosome -1.63 4.28e-2 118/152 (77.63%) SEC61A1;STX12;ATP6V1E1;...
Pyrimidine metabolism -1.63 4.27e-2 40/56 (71.43%) CAD;RRM1;UMPS;...
Ribosome biogenesis in eukaryotes -1.64 4.26e-2 52/108 (48.15%) SNU13;RPP30;LSG1;...
Pertussis -1.65 3.81e-2 64/76 (84.21%) TLR4;MAPK9;IL12A;...
Terpenoid backbone biosynthesis -1.67 3.36e-2 18/22 (81.82%) PCYOX1;ICMT;ACAT1;...
Cell cycle -1.67 3.51e-2 110/124 (88.71%) MAD2L1;CHEK2;CDC7;...
Small cell lung cancer -1.68 3.53e-2 90/92 (97.83%) E2F3;TRAF1;E2F1;...
Amoebiasis -1.68 3.71e-2 99/102 (97.06%) LAMC1;COL4A5;CD1B;...
Focal adhesion -1.69 3.56e-2 180/201 (89.55%) RASGRF1;LAMC1;COL4A5;...
Malaria -1.69 3.69e-2 44/50 (88%) ITGAL;TLR2;ICAM1;...
Measles -1.70 3.62e-2 133/139 (95.68%) TLR4;CASP8;MAPK9;...
Chagas disease -1.74 2.56e-2 93/102 (91.18%) PPP2R2A;TLR2;IKBKG;...
Rheumatoid arthritis -1.74 2.88e-2 78/93 (83.87%) HLA-DQB1;IL6;CXCL5;...
Regulation of lipolysis in adipocytes -1.77 2.35e-2 52/55 (94.55%) INS;ADCY7;GNAI2;...
IL-17 signaling pathway -1.83 1.10e-2 84/94 (89.36%) CASP8;MAPK9;MAPK7;...
Mismatch repair -1.83 1.32e-2 22/23 (95.65%) RPA1;MSH6;POLD1;...
Legionellosis -1.83 1.37e-2 51/57 (89.47%) CR1;HSPD1;NFKB2;...
DNA replication -2.11 0.00e+0 34/36 (94.44%) RPA1;POLE3;DNA2;...
Steroid biosynthesis -2.14 0.00e+0 19/20 (95%) CYP24A1;HSD17B7;CYP27B1;...
ECM-receptor interaction -2.18 0.00e+0 80/88 (90.91%) SV2B;SV2A;LAMA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H