Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYJ8Z3)

• Drug Name: Alprenolol Drug Info
• Synonyms: Alfeprol; Alpheprol; Alprenololum; Yobir; Alfeprol [Russian]; Alprenolol (INN); Alprenolol [INN:BAN]; Alprenololum [INN-Latin]; Apllobal (TN); Aptine (TN); Aptol (TN); Duriles (TN); Gubernal (TN); Regletin (TN); Yobir (TN); H-56-28; 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol; 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol; 1-(o-Allylphenoxy)-3-isopropylamino)-2-propanol; 1-(propan-2-ylamino)-3-(2-prop-2-enylphenoxy)propan-2-ol; 1-[2-(propen-2-ylphenoxy)]-3-(isopropylamino)propan-2-ol
• Therapeutic Class: Antiarrhythmic Agents
• Cross-matching ID:
  PubChem CID: 2119
  ChEBI ID: CHEMBL266195
  CAS Number: CAS 13655-52-2
  TTD Drug ID: D01VAB
  VARIDT Drug ID: DR00811
  INTEDE Drug ID: DR0076

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Fatty acid degradation	2.25	0.00e+0	40/43 (93.02%)	ACAA2;ACSBG1;ALDH2;...
Valine, leucine and isoleucine degradation	2.18	0.00e+0	42/48 (87.5%)	ACAA2;DLD;ABAT;...
Propanoate metabolism	2.14	0.00e+0	30/34 (88.24%)	DLD;ABAT;ECHDC1;...
PPAR signaling pathway	2.05	0.00e+0	66/74 (89.19%)	PLIN2;CD36;SORBS1;...
beta-Alanine metabolism	1.98	0.00e+0	25/30 (83.33%)	ABAT;DPYS;ALDH2;...
Ascorbate and aldarate metabolism	1.98	0.00e+0	15/30 (50%)	UGT2A3;ALDH2;ALDH7A1;...
Butanoate metabolism	1.97	0.00e+0	23/28 (82.14%)	ABAT;ACAT2;EHHADH;...
Tryptophan metabolism	1.95	0.00e+0	35/42 (83.33%)	MAOB;DLD;ALDH8A1;...
Glycolysis / Gluconeogenesis	1.93	0.00e+0	56/67 (83.58%)	FBP1;DLD;MINPP1;...
Peroxisome	1.91	0.00e+0	72/82 (87.8%)	SLC27A2;IDH2;ACAA1;...
Drug metabolism	1.88	2.33e-3	78/151 (51.66%)	GSTA1;MAOB;CYP3A5;...
Collecting duct acid secretion	1.87	4.26e-3	22/27 (81.48%)	CA2;ATP6V1A;SLC4A1;...
Fat digestion and absorption	1.86	3.94e-3	35/43 (81.4%)	CD36;ABCA1;PLPP3;...
Histidine metabolism	1.84	5.48e-3	16/22 (72.73%)	MAOB;HNMT;ALDH2;...
Glyoxylate and dicarboxylate metabolism	1.83	5.97e-3	23/30 (76.67%)	DLD;GLDC;SHMT1;...
Porphyrin and chlorophyll metabolism	1.81	9.59e-3	23/43 (53.49%)	PPOX;ALAD;UGT2A3;...
Lysine degradation	1.79	1.13e-2	51/63 (80.95%)	BBOX1;DLD;ALDH2;...
Fatty acid elongation	1.77	1.56e-2	19/27 (70.37%)	ACAA2;HACD2;ELOVL2;...
Inositol phosphate metabolism	1.76	1.55e-2	66/73 (90.41%)	PLCB1;MINPP1;PIK3CD;...
Primary bile acid biosynthesis	1.76	1.47e-2	15/17 (88.24%)	CYP39A1;AMACR;HSD17B4;...
Glycine, serine and threonine metabolism	1.75	1.40e-2	31/40 (77.5%)	MAOB;DLD;GLDC;...
Biosynthesis of unsaturated fatty acids	1.74	1.51e-2	21/27 (77.78%)	HACD2;ACAA1;ELOVL2;...
Retinol metabolism	1.73	1.78e-2	41/68 (60.29%)	CYP3A5;CYP3A7;UGT2A3;...
Citrate cycle (TCA cycle)	1.72	2.03e-2	30/30 (100%)	DLD;IDH2;IDH1;...
Phosphatidylinositol signaling system	1.72	1.94e-2	82/97 (84.54%)	PLCB1;PRKCA;PIK3CD;...
Endocrine and other factor-regulated calcium reabsorpti...	1.70	2.31e-2	49/53 (92.45%)	PLCB1;PRKCA;AP2S1;...
Sulfur relay system	1.67	2.51e-2	5/8 (62.5%)	TST;NFS1;MPST
Carbohydrate digestion and absorption	1.66	2.74e-2	37/47 (78.72%)	PLCB1;SLC37A4;PIK3CD;...
GABAergic synapse	1.65	3.26e-2	76/89 (85.39%)	PRKCA;GABBR1;ABAT;...
Sphingolipid signaling pathway	1.61	4.48e-2	106/119 (89.08%)	PLCB1;PRKCA;FCER1A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12.5uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼