Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYJGDK)

Drug Name
(+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one Drug Info
Synonyms 7-methoxy-2-(4-methoxyphenyl)chroman-4-one
Cross-matching ID
PubChem CID
5271544
ChEBI ID
CHEMBL229908
CAS Number
CAS 25826-69-1
TTD Drug ID
D00HVZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Parkinson disease 2.01 9.01e-3 176/249 (70.68%) ATP5F1C;PRKACB;CALML4;...
Proteasome 2.00 4.51e-3 44/46 (95.65%) PSMB8;PSMC1;PSMD2;...
Primary bile acid biosynthesis 1.78 4.81e-2 15/17 (88.24%) CYP27A1;AMACR;BAAT;...
Carbohydrate digestion and absorption -1.62 4.91e-2 37/47 (78.72%) PIK3CD;PIK3CB;PIK3CA;...
Th1 and Th2 cell differentiation -1.64 4.00e-2 80/92 (86.96%) HLA-DRA;MAPK1;GATA3;...
Fructose and mannose metabolism -1.64 4.20e-2 30/33 (90.91%) AKR1B1;PFKP;FBP1;...
Focal adhesion -1.66 4.08e-2 180/201 (89.55%) LAMA5;PDGFD;PDGFB;...
PI3K-Akt signaling pathway -1.66 4.24e-2 317/354 (89.55%) NGFR;LPAR1;NTRK2;...
Type II diabetes mellitus -1.67 4.24e-2 42/46 (91.3%) PKM;SOCS2;PIK3CD;...
Insulin resistance -1.68 3.67e-2 96/108 (88.89%) RPS6KB2;MLXIP;TRIB3;...
Asthma -1.71 2.75e-2 25/31 (80.65%) HLA-DRA;HLA-DPA1;CD40;...
Bladder cancer -1.72 2.94e-2 40/41 (97.56%) MAPK1;MMP1;MMP2;...
ECM-receptor interaction -1.74 2.00e-2 80/88 (90.91%) LAMA5;THBS4;ITGA2B;...
Fat digestion and absorption -1.75 2.07e-2 35/43 (81.4%) ACAT1;PNLIPRP1;PLA2G12A;...
TGF-beta signaling pathway -1.75 2.06e-2 81/94 (86.17%) RBX1;INHBA;TGFBR1;...
Pancreatic secretion -1.79 1.37e-2 87/102 (85.29%) SLC4A2;PRSS1;CTRB2;...
Biosynthesis of unsaturated fatty acids -1.79 1.50e-2 21/27 (77.78%) HSD17B4;ACOT7;FADS2;...
MicroRNAs in cancer -1.79 1.43e-2 146/310 (47.1%) CRKL;PIK3CD;PIK3CB;...
Aldosterone-regulated sodium reabsorption -1.79 1.61e-2 34/37 (91.89%) NEDD4L;HSD11B2;KCNJ1;...
Vitamin digestion and absorption -1.80 1.53e-2 17/24 (70.83%) PNLIP;CUBN;ABCC1;...
Thyroid hormone synthesis -1.81 1.79e-2 66/75 (88%) ADCY7;ATP1B1;ADCY3;...
Steroid biosynthesis -1.83 1.50e-2 19/20 (95%) NSDHL;FDFT1;SOAT2;...
Mineral absorption -1.84 1.88e-2 48/60 (80%) SLC5A1;SLC34A1;MT2A;...
Renin-angiotensin system -1.85 2.51e-2 20/23 (86.96%) ACE2;ENPEP;KLK2;...
Protein digestion and absorption -1.97 0.00e+0 78/103 (75.73%) KCNN4;COL8A2;COL8A1;...
Proximal tubule bicarbonate reclamation -2.03 0.00e+0 21/23 (91.3%) GLUD1;PCK1;AQP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H