Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYJV4I)

Drug Name
SL-327 Drug Info
Synonyms SL327
Cross-matching ID
PubChem CID
9549284
ChEBI ID
CHEMBL261237
CAS Number
CAS 305350-87-2
TTD Drug ID
D04WPA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Peroxisome 2.31 0.00e+0 72/82 (87.8%) SLC27A2;PEX2;ACOX1;...
Fatty acid degradation 2.13 0.00e+0 40/43 (93.02%) ACAT2;ALDH3A2;ACADL;...
Oxidative phosphorylation 2.12 0.00e+0 93/133 (69.92%) NDUFA4L2;ATP5PD;ATP5F1C;...
Valine, leucine and isoleucine degradation 2.08 0.00e+0 42/48 (87.5%) HMGCS2;ACAT2;ALDH3A2;...
Citrate cycle (TCA cycle) 2.04 1.79e-3 30/30 (100%) PCK1;IDH2;DLD;...
Ether lipid metabolism 1.94 2.98e-3 32/49 (65.31%) ENPP2;PLPP1;PLA2G2A;...
Histidine metabolism 1.90 6.38e-3 16/22 (72.73%) MAOA;ALDH3A2;ASPA;...
Primary bile acid biosynthesis 1.85 6.70e-3 15/17 (88.24%) HSD17B4;AMACR;SCP2;...
PPAR signaling pathway 1.82 1.39e-2 66/74 (89.19%) HMGCS2;SLC27A2;PCK1;...
Ascorbate and aldarate metabolism 1.79 1.79e-2 15/30 (50%) UGT2B17;ALDH3A2;AKR1A1;...
Glycolysis / Gluconeogenesis 1.76 2.27e-2 56/67 (83.58%) PCK1;ALDH3A2;PFKL;...
Pyruvate metabolism 1.75 2.23e-2 41/47 (87.23%) ACAT2;PCK1;ALDH3A2;...
Metabolism of xenobiotics by cytochrome P450 1.74 2.20e-2 49/77 (63.64%) UGT2B17;GSTA1;GSTA4;...
Propanoate metabolism 1.72 2.36e-2 30/34 (88.24%) ACAT2;ACOX1;ALDH6A1;...
Steroid hormone biosynthesis 1.68 3.45e-2 43/61 (70.49%) UGT2B17;AKR1C2;HSD11B2;...
Glyoxylate and dicarboxylate metabolism 1.67 3.74e-2 23/30 (76.67%) ACAT2;GLUL;CAT;...
Steroid biosynthesis 1.66 3.94e-2 19/20 (95%) LSS;DHCR24;TM7SF2;...
Nitrogen metabolism 1.64 4.37e-2 16/17 (94.12%) GLUL;CA12;CA4;...
Synthesis and degradation of ketone bodies 1.63 4.28e-2 9/10 (90%) HMGCS2;ACAT2;BDH2;...
Thiamine metabolism 1.62 4.42e-2 12/15 (80%) AK1;AK4;ALPL;...
Renin-angiotensin system 1.61 4.85e-2 20/23 (86.96%) MME;ENPEP;AGT;...
Arginine and proline metabolism 1.58 4.97e-2 39/50 (78%) MAOA;ALDH3A2;PRODH;...
Tryptophan metabolism 1.58 4.78e-2 35/42 (83.33%) ACAT2;MAOA;ALDH3A2;...
NF-kappa B signaling pathway -2.09 0.00e+0 90/104 (86.54%) TRAF5;TRAF1;BTK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H