Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYN8MA)

• Drug Name: Tianeptine Drug Info
• Synonyms: Tianeptina; Tianeptinum; Tianeptine Acid; Tianeptine [INN]; Stablon (TN); Tianeptine (INN); (1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide; 7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid; 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
• Cross-matching ID:
  PubChem CID: 68870
  ChEBI ID: CHEMBL91749
  CAS Number: CAS 72797-41-2
  TTD Drug ID: D06CVT
  VARIDT Drug ID: DR01101
  INTEDE Drug ID: DR1589

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	2.02	0.00e+0	110/124 (88.71%)	CDKN1B;SMAD3;CDKN2C;...
Metabolism of xenobiotics by cytochrome P450	1.90	8.22e-3	49/77 (63.64%)	CYP1B1;AKR1C1;EPHX1;...
Fanconi anemia pathway	1.89	5.48e-3	36/54 (66.67%)	REV3L;HES1;FANCL;...
Steroid hormone biosynthesis	1.77	4.31e-2	43/61 (70.49%)	CYP1B1;AKR1C3;AKR1C1;...
Retinol metabolism	1.77	3.45e-2	41/68 (60.29%)	ALDH1A1;DHRS3;RDH11;...
DNA replication	1.76	3.01e-2	34/36 (94.44%)	PCNA;RPA1;MCM3;...
p53 signaling pathway	1.75	2.82e-2	63/73 (86.3%)	DDB2;CCNG1;PERP;...
Proximal tubule bicarbonate reclamation	-1.70	1.55e-2	21/23 (91.3%)	ATP1B1;GLUD1;PCK1;...
Neutrophil extracellular trap formation	-1.70	1.56e-2	101/189 (53.44%)	ATG7;VDAC2;MAPK13;...
Regulation of actin cytoskeleton	-1.71	1.59e-2	185/218 (84.86%)	MAPK3;MYH14;MYH10;...
Thiamine metabolism	-1.74	1.47e-2	12/15 (80%)	AK5;AK2;ALPP;...
Acute myeloid leukemia	-1.75	1.31e-2	66/67 (98.51%)	FLT3;MAPK3;PIK3CD;...
Salmonella infection	-1.75	1.27e-2	198/249 (79.52%)	ARF1;PAK1;ARL8B;...
Hepatitis C	-1.76	1.28e-2	139/157 (88.54%)	CASP3;MAPK3;CLDN18;...
Synaptic vesicle cycle	-1.78	7.92e-3	63/78 (80.77%)	ATP6V1G1;SLC6A4;ATP6V0E1;...
MAPK signaling pathway	-1.81	5.69e-3	272/294 (92.52%)	CACNB1;TNF;MAP3K11;...
Leukocyte transendothelial migration	-1.83	4.33e-3	90/114 (78.95%)	PTPN11;CLDN18;PIK3CD;...
Neurotrophin signaling pathway	-1.84	3.98e-3	107/119 (89.92%)	RAPGEF1;GAB1;MATK;...
Renal cell carcinoma	-1.87	2.99e-3	68/69 (98.55%)	HGF;PAK1;EGLN1;...
Yersinia infection	-1.88	3.16e-3	120/137 (87.59%)	ARHGEF28;MYD88;FYB1;...
AGE-RAGE signaling pathway in diabetic complications	-1.88	3.35e-3	97/100 (97%)	CASP3;TGFB3;MAPK3;...
Bladder cancer	-1.89	2.84e-3	40/41 (97.56%)	RB1;MAPK1;DAPK3;...
C-type lectin receptor signaling pathway	-1.89	3.03e-3	93/104 (89.42%)	TNF;MAPK13;BCL3;...
T cell receptor signaling pathway	-1.90	2.44e-3	93/104 (89.42%)	MAPK3;NFKBIE;PIK3CD;...
Tuberculosis	-1.90	2.63e-3	159/180 (88.33%)	TCIRG1;CASP3;TGFB3;...
Malaria	-1.93	9.48e-4	44/50 (88%)	SDC1;IL1B;THBS1;...
IL-17 signaling pathway	-1.93	1.03e-3	84/94 (89.36%)	TRAF3IP2;HSP90AB1;TRAF4;...
Pathogenic Escherichia coli infection	-1.94	1.14e-3	152/197 (77.16%)	ARF1;PAK1;NCK2;...
Leishmaniasis	-1.96	0.00e+0	67/77 (87.01%)	TGFB3;MAPK3;NFKBIB;...
Pertussis	-1.97	0.00e+0	64/76 (84.21%)	CD14;TRAF6;FOS;...
Complement and coagulation cascades	-1.97	0.00e+0	76/85 (89.41%)	PLAU;ITGAM;C1QA;...
Hematopoietic cell lineage	-2.03	0.00e+0	90/99 (90.91%)	CD3D;CR2;CSF2;...
TNF signaling pathway	-2.06	0.00e+0	103/112 (91.96%)	MAP2K4;CASP3;MAPK3;...
NF-kappa B signaling pathway	-2.09	0.00e+0	90/104 (86.54%)	CCL13;NFKB1;TRIM25;...
Epithelial cell signaling in Helicobacter pylori infect...	-2.09	0.00e+0	62/70 (88.57%)	GIT1;CXCL1;CXCR1;...
Rheumatoid arthritis	-2.14	0.00e+0	78/93 (83.87%)	TCIRG1;TGFB3;HLA-DPA1;...
Phagosome	-2.17	0.00e+0	118/152 (77.63%)	CORO1A;ATP6V1G1;TAP2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H, 24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
1HAEo-	CVCL_0128	Homo sapiens	10uM	24H	Show ▼
NL20	CVCL_0461	Homo sapiens	10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Normal (Fibroblast)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HFL1	CVCL_4295	Homo sapiens	10uM	24H	Show ▼
IMR-90	CVCL_0347	Homo sapiens	10uM	24H	Show ▼
WI-38	CVCL_0579	Homo sapiens	10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H, 24H	Show ▼