Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYO8T6)

Drug Name
MK-212 Drug Info
Synonyms 64022-27-1
Cross-matching ID
PubChem CID
107992
ChEBI ID
CHEMBL269521
CAS Number
CAS 64022-27-1
TTD Drug ID
D02ESW

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Primary bile acid biosynthesis 2.00 1.19e-2 15/17 (88.24%) AMACR;CYP7A1;SLC27A5;...
Pertussis 1.95 5.94e-3 64/76 (84.21%) C1R;C1S;RHOA;...
Complement and coagulation cascades 1.94 7.92e-3 76/85 (89.41%) F12;C1R;C1S;...
Metabolism of xenobiotics by cytochrome P450 1.86 2.67e-2 49/77 (63.64%) GSTA4;HSD11B1;ALDH3A1;...
Staphylococcus aureus infection 1.86 2.14e-2 72/95 (75.79%) C1R;C1S;C3;...
Viral protein interaction with cytokine and cytokine re... 1.86 1.78e-2 84/100 (84%) TNFSF10;CXCL1;IL2RB;...
TNF signaling pathway 1.84 1.70e-2 103/112 (91.96%) JUNB;CXCL1;MMP9;...
IL-17 signaling pathway 1.82 1.78e-2 84/94 (89.36%) S100A9;CXCL1;MUC5B;...
Natural killer cell mediated cytotoxicity 1.79 2.64e-2 99/131 (75.57%) TNFSF10;PRF1;KLRK1;...
Amoebiasis 1.77 3.09e-2 99/102 (97.06%) CXCL1;SERPINB4;SERPINB3;...
Bile secretion 1.73 4.64e-2 68/90 (75.56%) ABCG2;SCARB1;CYP7A1;...
Steroid hormone biosynthesis 1.73 4.25e-2 43/61 (70.49%) HSD11B1;CYP7A1;SRD5A1;...
Graft-versus-host disease 1.73 4.11e-2 32/42 (76.19%) PRF1;GZMB;HLA-B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H