Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYOP45)

Drug Name
Piceatannol Drug Info
Synonyms
piceatannol; 10083-24-6; 3-Hydroxyresveratol; piceatanol; astringinin; 3,5,3',4'-Tetrahydroxystilbene; (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol; 3,3',4'5-Tetrahydroxystilbene; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol; 3,3',4,5'-Tetrahydroxystilbene; UNII-6KS3LS0D4F; NSC 365798; NSC-365798; NSC 622471; 6KS3LS0D4F; CHEMBL69863; 3,3',4,5'-Stilbenetetrol; 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol; 4339-71-3; CHEBI:28814; C14H12O4; NSC365798; NSC622471; 1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-
Cross-matching ID
PubChem CID
667639
ChEBI ID
CHEMBL28814
CAS Number
CAS 10083-24-6
TTD Drug ID
D0O0VZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.57 0.00e+0 127/171 (74.27%) HSPA2;HERPUD1;HSPA1A;...
Metabolism of xenobiotics by cytochrome P450 2.44 0.00e+0 49/77 (63.64%) AKR1C1;ALDH3A1;CBR3;...
Pentose and glucuronate interconversions 2.33 0.00e+0 17/34 (50%) AKR1B10;UGT2B28;UGDH;...
Steroid hormone biosynthesis 2.16 0.00e+0 43/61 (70.49%) AKR1C3;AKR1C1;AKR1C2;...
Ascorbate and aldarate metabolism 2.13 0.00e+0 15/30 (50%) UGT2B28;UGDH;UGT2B15;...
Porphyrin and chlorophyll metabolism 2.11 0.00e+0 23/43 (53.49%) HMOX1;CP;UGT2B28;...
Bile secretion 2.06 0.00e+0 68/90 (75.56%) ABCC3;UGT2B28;AQP9;...
Drug metabolism 2.05 0.00e+0 78/151 (51.66%) ALDH3A1;UGT2B28;GSTA4;...
Complement and coagulation cascades 2.04 0.00e+0 76/85 (89.41%) CFB;CLU;SERPINA1;...
Retinol metabolism 2.00 8.90e-4 41/68 (60.29%) UGT2B28;UGT2B15;ADH7;...
Arachidonic acid metabolism 2.00 8.09e-4 48/61 (78.69%) AKR1C3;GPX2;CBR3;...
Folate biosynthesis 1.99 7.42e-4 23/26 (88.46%) AKR1C3;AKR1B10;GGH;...
N-Glycan biosynthesis 1.99 6.85e-4 38/50 (76%) RPN1;GANAB;MGAT2;...
Ferroptosis 1.97 1.27e-3 36/41 (87.8%) HMOX1;GCLM;CP;...
Glutathione metabolism 1.96 1.19e-3 43/57 (75.44%) GPX2;GCLM;GSTA4;...
Amino sugar and nucleotide sugar metabolism 1.95 1.11e-3 38/48 (79.17%) UGDH;GFPT2;GFPT1;...
Mineral absorption 1.93 1.57e-3 48/60 (80%) HMOX1;FTH1;MT1X;...
Lysosome 1.91 2.97e-3 115/128 (89.84%) MCOLN1;ACP2;PSAP;...
Sulfur metabolism 1.91 2.81e-3 9/10 (90%) TST;PAPSS2;SUOX;...
Antigen processing and presentation 1.91 3.12e-3 60/78 (76.92%) HSPA2;HSPA1A;HSPA6;...
Various types of N-glycan biosynthesis 1.87 4.66e-3 26/39 (66.67%) RPN1;MGAT2;FUT8;...
Riboflavin metabolism 1.86 4.45e-3 7/8 (87.5%) ACP2;ACP5;BLVRB;...
Legionellosis 1.85 4.64e-3 51/57 (89.47%) HSPA2;HSPA1A;HSPA6;...
Ovarian steroidogenesis 1.84 5.56e-3 41/51 (80.39%) AKR1C3;ALOX5;CYP1B1;...
Viral protein interaction with cytokine and cytokine re... 1.83 5.34e-3 84/100 (84%) TNFSF10;CXCL6;CXCL8;...
Steroid biosynthesis 1.83 5.48e-3 19/20 (95%) LIPA;SC5D;MSMO1;...
Linoleic acid metabolism 1.83 5.28e-3 21/29 (72.41%) PLAAT3;CYP2C9;ALOX15;...
Pertussis 1.80 6.14e-3 64/76 (84.21%) CXCL6;CXCL8;CD14;...
Pentose phosphate pathway 1.80 5.93e-3 25/30 (83.33%) G6PD;PGD;TKT;...
Selenocompound metabolism 1.80 5.74e-3 11/17 (64.71%) TXNRD1;PAPSS2;SEPHS2;...
Relaxin signaling pathway -1.66 4.83e-2 114/129 (88.37%) CREB1;EDNRB;TGFBR1;...
DNA replication -1.68 4.72e-2 34/36 (94.44%) MCM3;PRIM2;PCNA;...
Thyroid hormone signaling pathway -1.69 4.72e-2 112/121 (92.56%) HDAC3;PFKP;NRAS;...
RNA polymerase -1.72 4.05e-2 23/31 (74.19%) POLR3F;POLR2A;POLR3C;...
RNA transport -1.81 1.97e-2 128/186 (68.82%) SAP18;PAIP1;EIF2B3;...
TGF-beta signaling pathway -1.82 2.12e-2 81/94 (86.17%) TGFB1;BMP2;CUL1;...
Ribosome biogenesis in eukaryotes -1.84 2.07e-2 52/108 (48.15%) NHP2;TBL3;TCOF1;...
Spliceosome -1.90 7.87e-3 101/150 (67.33%) SYF2;SNRPG;SMNDC1;...
Oocyte meiosis -1.92 1.18e-2 90/129 (69.77%) ANAPC5;PPP2CA;REC8;...
Cell cycle -2.11 0.00e+0 110/124 (88.71%) BUB1B;CCNA1;SMC3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 3.33uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H