Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYR8SG)

Drug Name
Tubacin Drug Info
Synonyms
Tubacin; 537049-40-4; AC1O7Y2P; CHEMBL356769; 1350555-93-9; N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide; Tubacin (BML-GR362); Octanediamide, N1-(4-((2R,4R,6S)-4-(((4,5-diphenyl-2-oxazolyl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy-, rel-; N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide; SCHEMBL4741166
Cross-matching ID
PubChem CID
6675804
ChEBI ID
CHEMBL356769
CAS Number
CAS 537049-40-4
TTD Drug ID
D04KQF

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
HIF-1 signaling pathway 2.00 0.00e+0 105/109 (96.33%) ENO2;PFKP;HK2;...
Type II diabetes mellitus 1.90 9.56e-3 42/46 (91.3%) HK2;PRKCZ;HK1;...
Autophagy 1.84 2.23e-2 113/169 (66.86%) BNIP3;DDIT4;RRAS2;...
Fructose and mannose metabolism 1.84 1.91e-2 30/33 (90.91%) PFKP;HK2;PFKFB3;...
Glycolysis / Gluconeogenesis 1.82 2.10e-2 56/67 (83.58%) ENO2;PFKP;HK2;...
Oxidative phosphorylation 1.75 4.30e-2 93/133 (69.92%) ATP5PD;NDUFV2;ATP5F1C;...
Pentose phosphate pathway 1.74 3.82e-2 25/30 (83.33%) PFKP;ALDOC;PGM1;...
Pertussis -1.63 4.63e-2 64/76 (84.21%) IRF8;C2;IL23A;...
Protein digestion and absorption -1.63 4.87e-2 78/103 (75.73%) COL7A1;SLC7A7;SLC7A8;...
Toxoplasmosis -1.65 4.16e-2 103/112 (91.96%) HLA-DQA1;ALOX5;NFKBIB;...
Steroid hormone biosynthesis -1.67 3.92e-2 43/61 (70.49%) UGT2A3;CYP1A1;UGT2B28;...
One carbon pool by folate -1.73 2.02e-2 15/20 (75%) DHFR;MTHFS;SHMT2;...
Systemic lupus erythematosus -1.78 1.25e-2 45/135 (33.33%) ACTN1;IFNG;HLA-DQA1;...
Complement and coagulation cascades -1.78 1.34e-2 76/85 (89.41%) FGB;CLU;PLG;...
Lipid and atherosclerosis -1.79 1.36e-2 190/215 (88.37%) PIK3R3;NCF2;CASP6;...
Renin-angiotensin system -1.79 1.47e-2 20/23 (86.96%) ACE2;ENPEP;CTSG;...
NF-kappa B signaling pathway -1.81 1.32e-2 90/104 (86.54%) RELB;RIPK1;TLR4;...
DNA replication -1.81 1.46e-2 34/36 (94.44%) POLA2;POLD4;PCNA;...
Proximal tubule bicarbonate reclamation -1.82 1.62e-2 21/23 (91.3%) SLC4A4;ATP1B1;PCK2;...
ECM-receptor interaction -1.87 1.17e-2 80/88 (90.91%) THBS2;TNXB;TNN;...
Rheumatoid arthritis -1.94 8.92e-3 78/93 (83.87%) IFNG;CSF2;CSF1;...
Cytokine-cytokine receptor interaction -1.96 8.67e-3 246/295 (83.39%) TNFSF18;INHBB;CD4;...
TNF signaling pathway -2.05 2.08e-3 103/112 (91.96%) CASP7;IRF1;FAS;...
IL-17 signaling pathway -2.05 2.60e-3 84/94 (89.36%) HSP90AA1;TNFAIP3;IL17RA;...
Malaria -2.08 3.47e-3 44/50 (88%) THBS2;IFNG;KLRB1;...
Viral protein interaction with cytokine and cytokine re... -2.27 0.00e+0 84/100 (84%) CSF1;CCR10;CCL4;...
Staphylococcus aureus infection -2.35 0.00e+0 72/95 (75.79%) FCGR3B;KRT10;C5;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H