Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYSJRN)

• Drug Name: Bromopride Drug Info
• Synonyms: Bromopride hydrochloride; UNII-B7C7WX94Z6; B7C7WX94Z6; 52423-56-0; 4-amino-5-bromo-N-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride; Cascapride; Opridan; Bromopride HCl; Bromoprid hydrochlorid; EINECS 257-906-6; AC1MI3LY; SCHEMBL8385045; CTK8J0119; AKOS027380919; KB-289931; 4-Amino-5-bromo-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride
• Cross-matching ID:
  PubChem CID: 2446
  ChEBI ID: CHEMBL399510
  CAS Number: CAS 4093-35-0
  TTD Drug ID: D09WEJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.10	8.05e-3	76/85 (89.41%)	CLU;PLAT;CFH;...
Butanoate metabolism	1.98	1.21e-2	23/28 (82.14%)	ABAT;OXCT1;ALDH5A1;...
Influenza A	-1.69	4.16e-2	156/172 (90.7%)	EP300;AKT2;NFKBIB;...
Viral myocarditis	-1.70	4.18e-2	53/60 (88.33%)	RAC2;HLA-A;HLA-DQA1;...
Natural killer cell mediated cytotoxicity	-1.79	1.97e-2	99/131 (75.57%)	SYK;GRB2;KLRD1;...
Leishmaniasis	-1.81	1.61e-2	67/77 (87.01%)	HLA-DQA1;ITGB2;JAK2;...
Type I diabetes mellitus	-1.84	1.64e-2	38/43 (88.37%)	HLA-A;HLA-DQA1;HLA-B;...
Rheumatoid arthritis	-1.84	1.69e-2	78/93 (83.87%)	FLT1;IL11;CD86;...
Hematopoietic cell lineage	-1.96	6.58e-3	90/99 (90.91%)	GP1BB;IL5RA;IL3RA;...
Allograft rejection	-2.17	0.00e+0	32/38 (84.21%)	HLA-A;HLA-DQA1;HLA-B;...
Graft-versus-host disease	-2.25	0.00e+0	32/42 (76.19%)	GZMB;CD86;IL1A;...
Asthma	-2.32	0.00e+0	25/31 (80.65%)	MS4A2;EPX;HLA-DQA1;...
Autoimmune thyroid disease	-2.33	0.00e+0	46/53 (86.79%)	TG;HLA-A;HLA-DQA1;...
Antigen processing and presentation	-2.41	0.00e+0	60/78 (76.92%)	TAP2;HSPA5;CANX;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲