Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYTGW0)

• Drug Name: Celiprolol Drug Info
• Synonyms: Celectol; Celiprolol [INN:BAN]; Celiprololum; Celiprololum [INN-Latin]; RHC 5320 A; RHC-5320A; ST-1396; Selectol; UL/1677; celiprolol; 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea; 56980-93-9; BRN 2776298; CCRIS 3400; EINECS 260-497-7; N'-(3-Acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-N,N-diethylurea; Urea, N'-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-N,N-diethyl-
• Cross-matching ID:
  PubChem CID: 2663
  ChEBI ID: CHEMBL94461
  CAS Number: CAS 56980-93-9
  INTEDE Drug ID: DR0287

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
NF-kappa B signaling pathway	2.12	0.00e+0	90/104 (86.54%)	BIRC3;CXCL1;LTB;...
Rheumatoid arthritis	2.09	0.00e+0	78/93 (83.87%)	CCL20;CXCL1;LTB;...
Cytosolic DNA-sensing pathway	2.06	0.00e+0	52/63 (82.54%)	NFKBIB;IL1B;IL6;...
TNF signaling pathway	2.03	0.00e+0	103/112 (91.96%)	CCL20;JAG1;BIRC3;...
IL-17 signaling pathway	2.00	0.00e+0	84/94 (89.36%)	CCL20;S100A7;CXCL1;...
Viral protein interaction with cytokine and cytokine re...	1.96	2.98e-3	84/100 (84%)	CCL20;CXCL1;CXCL14;...
Th1 and Th2 cell differentiation	1.80	1.91e-2	80/92 (86.96%)	NFKBIB;JAG1;LCK;...
Cytokine-cytokine receptor interaction	1.76	2.34e-2	246/295 (83.39%)	CCL20;CXCL1;BMP2;...
Porphyrin and chlorophyll metabolism	-1.79	3.77e-2	23/43 (53.49%)	CPOX;PPOX;BLVRA;...
Glycolysis / Gluconeogenesis	-1.80	4.16e-2	56/67 (83.58%)	ADH1A;ADPGK;DLAT;...
Glycine, serine and threonine metabolism	-1.83	2.96e-2	31/40 (77.5%)	GCAT;SRR;GRHPR;...
Steroid biosynthesis	-1.88	1.66e-2	19/20 (95%)	LIPA;LSS;TM7SF2;...
Ferroptosis	-1.97	1.11e-2	36/41 (87.8%)	HMOX1;GPX4;ALOX15;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲