Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYURI6)

Drug Name
Raltegravir Drug Info
Synonyms
RGV; MK 0518; Isentress(TM); K-0518; MK-0518; Raltegravir (INN); N-(2-(4-(4-fluorobenzylcarbamoyl); N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-4-pyrimidinecarboxamide; RAL
Cross-matching ID
PubChem CID
54671008
ChEBI ID
CHEMBL254316
CAS Number
CAS 518048-05-0
TTD Drug ID
D0I1FQ
INTEDE Drug ID
DR1390
ACDINA Drug ID
D00580

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 2.23 0.00e+0 113/158 (71.52%) RPS4Y1;MRPL15;MRPL13;...
Oxidative phosphorylation 1.94 9.15e-3 93/133 (69.92%) COX5B;ATP5MG;COX17;...
Fanconi anemia pathway 1.91 6.10e-3 36/54 (66.67%) RPA3;CENPX;FANCI;...
DNA replication 1.87 1.07e-2 34/36 (94.44%) PCNA;RPA3;POLE2;...
Homologous recombination 1.80 2.81e-2 35/41 (85.37%) RPA3;NBN;RAD54B;...
Spliceosome 1.75 3.76e-2 101/150 (67.33%) HSPA2;SF3A2;PRPF4;...
RNA polymerase 1.74 3.84e-2 23/31 (74.19%) POLR2I;POLR3K;POLR2D;...
Parkinson disease 1.74 3.58e-2 176/249 (70.68%) PSMA3;COX5B;GPR37;...
Thermogenesis 1.70 4.34e-2 173/232 (74.57%) MAPK13;MGLL;COX5B;...
Lipid and atherosclerosis -1.71 4.72e-2 190/215 (88.37%) CALML4;LDLR;MAPK14;...
Arginine and proline metabolism -1.77 2.42e-2 39/50 (78%) ALDH18A1;PRODH2;NOS2;...
Nicotine addiction -1.78 2.36e-2 32/40 (80%) GABRA5;GABRG3;CACNA1B;...
Hypertrophic cardiomyopathy -1.86 8.49e-3 81/90 (90%) ITGB7;CACNA1S;CACNB2;...
Bladder cancer -1.88 3.54e-3 40/41 (97.56%) DAPK3;DAPK2;KRAS;...
beta-Alanine metabolism -1.88 4.72e-3 25/30 (83.33%) ALDH3A2;HADHA;DPYD;...
Ferroptosis -1.89 7.07e-3 36/41 (87.8%) PRNP;MAP1LC3B;SLC3A2;...
NOD-like receptor signaling pathway -1.99 0.00e+0 145/181 (80.11%) TYK2;RIPK2;PSTPIP1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H