Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYVOL9)

Drug Name
icilin Drug Info
Synonyms
Icilin; 36945-98-9; AG 3-5; 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one; Icilin(AG 3-5); UNII-CS70PZQ4QJ; ICILLIN; 2(1H)-Pyrimidinone, 3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-; CS70PZQ4QJ; BRN 0700310; CHEMBL258405; 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone; AG-3-5; 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one; 2(1H)-Pyrimidinone,3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-
Cross-matching ID
PubChem CID
161930
ChEBI ID
CHEMBL258405
CAS Number
CAS 36945-98-9
TTD Drug ID
D04ULU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 1.96 0.00e+0 84/94 (89.36%) CCL20;S100A7;S100A9;...
Ribosome 1.87 1.38e-2 113/158 (71.52%) MRPS2;RPL5;RPL10;...
DNA replication 1.84 1.53e-2 34/36 (94.44%) PCNA;MCM4;RPA3;...
Proteasome -1.65 4.60e-2 44/46 (95.65%) PSMC6;PSMF1;PSMD1;...
Adherens junction -1.65 4.87e-2 63/71 (88.73%) CTNNA2;PTPRB;RAC2;...
p53 signaling pathway -1.67 4.92e-2 63/73 (86.3%) PTEN;BBC3;CCNG2;...
Glycosaminoglycan degradation -1.70 4.40e-2 19/19 (100%) HPSE;GLB1;HEXA;...
Viral myocarditis -1.70 4.89e-2 53/60 (88.33%) HLA-C;HLA-E;RAC2;...
Phagosome -1.83 3.93e-2 118/152 (77.63%) DYNC1I2;ITGB1;HLA-F;...
Complement and coagulation cascades -1.86 4.83e-2 76/85 (89.41%) C1QB;CFHR5;ITGAX;...
Lysosome -2.16 0.00e+0 115/128 (89.84%) AP1G1;SLC17A5;GGA2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H