Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMYX7NI)

Drug Name
Acetohydroxamic Acid Drug Info
Synonyms
AHA; Acethydroxamsaeure; Acethydroxamsaure; Acetohydroxamate; HAE; Lithostat; Acethydroxamic acid; Acethydroxamsaeure [German]; Acetohydroximic acid; Acetyl hydroxyamino; Acetylhydroxamic acid; Acide acetohydroxamique; Acide acetohydroxamique [French]; Acido acetohidroxamico; Acido acetohidroxamico [Spanish]; Acidum acetohydroxamicum; Acidum acetohydroxamicum [Latin]; Cetohyroxamic acid; Methylhydroxamic acid; SJX HLdmMAH; AHA (TN); Acetic acid, oxime; Acetohydroxamic acid [USAN:INN]; Lithostat (TN); N-Acetyl hydroxyacetamide; N-Acetylhydroxylamine; N-Hydroxyacetamide; N-hydroxyacetimidic acid; N-hydroxyethanimidic acid; S14-0751; Acetohydroxamic acid (USP/INN); Acetamide, N-hydroxy-(9CI)
Therapeutic ClassAntiinfective Agents
Cross-matching ID
PubChem CID
1990
ChEBI ID
CHEMBL27777
CAS Number
CAS 546-88-3
TTD Drug ID
D0R9BG
ACDINA Drug ID
D00805

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 1.97 2.38e-2 101/150 (67.33%) SNRPA1;SNRPB2;SNRNP200;...
DNA replication 1.94 2.38e-2 34/36 (94.44%) PCNA;MCM6;RFC2;...
Cell cycle 1.92 1.85e-2 110/124 (88.71%) PCNA;CDC20;MCM6;...
Ribosome biogenesis in eukaryotes 1.85 3.17e-2 52/108 (48.15%) EIF6;NOP56;IMP4;...
Mismatch repair 1.81 3.81e-2 22/23 (95.65%) PCNA;RFC2;POLD2;...
ECM-receptor interaction 1.80 3.17e-2 80/88 (90.91%) COL6A1;COL1A2;COL6A3;...
Proteasome 1.79 3.29e-2 44/46 (95.65%) PSMB1;PSMB3;PSMD11;...
Allograft rejection -1.89 1.99e-2 32/38 (84.21%) HLA-C;HLA-B;HLA-A;...
Type I diabetes mellitus -2.00 1.19e-2 38/43 (88.37%) HLA-C;HLA-B;HLA-A;...
Graft-versus-host disease -2.08 1.19e-2 32/42 (76.19%) HLA-C;HLA-B;HLA-A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H