Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ0D3V)

Drug Name
GRC-6211 Drug Info
Synonyms
Oxolinic acid; oxolinic acid; 14698-29-4; Nidantin; Prodoxol; Prodoxal; Emyrenil; Dioxacin; Gramurin; Oxolinic; Oksaren; Ossian; Uroxol; Utibid; Urotrate; Uritrate; Pietil; Oxoboi; Ultibid; Starner; Acido oxolinico; Uro-alvar; Acide oxolinique; Acidum oxolinicum; Cistopax; Tiurasin; Orthurine; Acido ossolico; 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid; NSC-110364; Urinox; Acido ossolico [DCIT]; 5-Ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid; 1-Ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylic acid; GRC-6127; TRPV1 antagonists (asthma), Glenmark/Lilly; TRPV1 antagonists (incontinence), Glenmark/Lilly; TRPV1 antagonists (pain), Glenmark/Lilly; Transient receptor potential vanilloid sub-family 1 (pain), Glenmark/ Lilly; Vanilloid receptor VR1 antagonists (incontinence/pain/asthma), Glenmark/Lilly
Cross-matching ID
PubChem CID
138393987
TTD Drug ID
D00MAN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glutathione metabolism 1.96 1.97e-2 43/57 (75.44%) GSTA4;HPGDS;GSTM3;...
Oxidative phosphorylation 1.93 9.83e-3 93/133 (69.92%) NDUFA4;ATP6V1D;NDUFB6;...
Huntington disease 1.88 1.97e-2 233/306 (76.14%) POLR2I;STX1A;NDUFA4;...
Proteasome 1.85 2.46e-2 44/46 (95.65%) PSMB6;PSMD4;PSMD2;...
Steroid biosynthesis 1.83 2.16e-2 19/20 (95%) DHCR24;DHCR7;SOAT1;...
Drug metabolism 1.80 2.46e-2 78/151 (51.66%) GSTA4;CES1;UPP1;...
AGE-RAGE signaling pathway in diabetic complications -1.82 3.79e-2 97/100 (97%) IL6;JUN;TGFB2;...
Protein digestion and absorption -2.13 0.00e+0 78/103 (75.73%) COL13A1;CELA2A;COL18A1;...
ECM-receptor interaction -2.23 0.00e+0 80/88 (90.91%) COL2A1;HSPG2;COL4A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 24H