Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ0DMY)

• Drug Name: LY2874455 Drug Info
• Synonyms: LY2874455; 1254473-64-7; LY-2874455; UNII-E9M363811V; CHEMBL3828009; E9M363811V; AK186860; LY 2874455; (R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; C21H19Cl2N5O2; (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; GKJCVYLDJWTWQU-CXLRFSCWSA-N; SCHEMBL298446; SCHEMBL298445; QCR-90; GTPL8104; DTXSID20154776; MolPort-044-724-281; MolPort-023-219-117; EX-A1340; BCP04756; ZINC73069242; BDBM50189781; 2529AH; s7057; AKOS027251051
• Cross-matching ID:
  PubChem CID: 46944259
  ChEBI ID: CHEMBL3828009
  CAS Number: CAS 1254473-64-7
  TTD Drug ID: D0D4VV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.09	0.00e+0	93/133 (69.92%)	ATP5MC2;NDUFB1;NDUFV1;...
Butanoate metabolism	1.87	2.24e-2	23/28 (82.14%)	ALDH5A1;HADHA;ABAT;...
Mineral absorption	1.81	2.61e-2	48/60 (80%)	MT1E;MT1F;MT1G;...
Thermogenesis	1.76	4.48e-2	173/232 (74.57%)	PRKACB;ATP5MC2;NDUFB1;...
Diabetic cardiomyopathy	1.75	4.48e-2	162/203 (79.8%)	ATP5MC2;GAPDH;NDUFB1;...
Legionellosis	-1.77	3.08e-2	51/57 (89.47%)	TLR5;EEF1A2;SAR1B;...
Ribosome biogenesis in eukaryotes	-1.90	1.28e-2	52/108 (48.15%)	EIF6;XPO1;RPP40;...
DNA replication	-2.04	0.00e+0	34/36 (94.44%)	POLD3;PRIM2;POLA1;...
Glycosaminoglycan biosynthesis	-2.07	0.00e+0	40/58 (68.97%)	NDST4;B4GALT7;CHST1;...
Proteasome	-2.12	0.00e+0	44/46 (95.65%)	PSMB6;PSMB3;PSMD13;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼