Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ1FRS)

• Drug Name: Propidium Drug Info
• Synonyms: PROPIDIUM; 36015-30-2; UNII-74NX23J96Y; CHEBI:51246; 74NX23J96Y; 3,8-DIAMINO-5[3-(DIETHYLMETHYLAMMONIO)PROPYL]-6-PHENYLPHENANTHRIDINIUM; Phenanthridinium, 3,8-diamino-5-(3-(diethylmethylammonio)propyl)-6-phenyl-; 3,8-diamino-5-{3-[diethyl(methyl)ammonio]propyl}-6-phenylphenanthridinium; CHEMBL345124; PRM; Propidium Iodide, 2; AC1Q1IXP; Prestwick1_000792; Prestwick0_000792; Prestwick2_000792; Prestwick3_000792; AC1L1J9Q; CBiol_001968; SCHEMBL55279; BSPBio_000924; KBioSS_000378; KBioGR_000378; BSPBio_001038; SPBio_002863
• Cross-matching ID:
  PubChem CID: 4939
  ChEBI ID: CHEMBL332935
  CAS Number: CAS 36015-30-2
  TTD Drug ID: D08UET

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Galactose metabolism	1.97	7.10e-3	26/31 (83.87%)	PFKP;HK2;G6PC3;...
IL-17 signaling pathway	-1.68	3.63e-2	84/94 (89.36%)	TRAF3;JUN;MAPK1;...
T cell receptor signaling pathway	-1.68	3.62e-2	93/104 (89.42%)	IL5;ZAP70;PPP3R1;...
NOD-like receptor signaling pathway	-1.72	2.06e-2	145/181 (80.11%)	IRF3;OAS2;TRAF6;...
Viral protein interaction with cytokine and cytokine re...	-1.74	1.91e-2	84/100 (84%)	TNFSF14;CXCL13;IL10;...
Primary immunodeficiency	-1.77	1.49e-2	33/38 (86.84%)	ZAP70;CD40;IL2RG;...
Leishmaniasis	-1.77	1.65e-2	67/77 (87.01%)	TRAF6;NFKBIB;CR1;...
Type I diabetes mellitus	-1.78	1.86e-2	38/43 (88.37%)	HLA-F;ICA1;CD86;...
African trypanosomiasis	-1.78	2.12e-2	32/37 (86.49%)	MYD88;IL10;HBB;...
Malaria	-1.81	1.86e-2	44/50 (88%)	CD81;CD40;GYPC;...
Allograft rejection	-2.03	0.00e+0	32/38 (84.21%)	IL2;CD28;HLA-F;...
Graft-versus-host disease	-2.09	0.00e+0	32/42 (76.19%)	HLA-F;CD86;FASLG;...
NF-kappa B signaling pathway	-2.12	0.00e+0	90/104 (86.54%)	LCK;TRAF3;ERC1;...
TNF signaling pathway	-2.22	0.00e+0	103/112 (91.96%)	MAP2K3;MMP14;TRAF3;...
Rheumatoid arthritis	-2.28	0.00e+0	78/93 (83.87%)	CSF2;FOS;TLR4;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲