General Information of Drug (ID: DMZ1OO0)

Drug Name
AS-1949490 Drug Info
Synonyms SH2 domain inositol phosphatase inhibitor (type 2 diabetes), Astellas
Cross-matching ID
PubChem CID
44473434
ChEBI ID
CHEMBL2337806
TTD Drug ID
D09IKZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Intestinal immune network for IgA production 2.03 0.00e+0 38/48 (79.17%) CD40;TNFSF13;HLA-DQA1;...
Allograft rejection 1.97 0.00e+0 32/38 (84.21%) CD40;HLA-DQA1;HLA-DPB1;...
Pentose and glucuronate interconversions 1.95 0.00e+0 17/34 (50%) UGT2A3;AKR1B1;AKR1B10;...
Autoimmune thyroid disease 1.93 6.44e-3 46/53 (86.79%) CD40;HLA-DQA1;HLA-DPB1;...
Inflammatory bowel disease 1.92 5.15e-3 58/65 (89.23%) TLR4;HLA-DQA1;HLA-DPB1;...
Protein digestion and absorption 1.90 4.29e-3 78/103 (75.73%) COL9A2;COL6A1;COL9A3;...
Asthma 1.87 9.20e-3 25/31 (80.65%) CD40;HLA-DQA1;HLA-DPB1;...
Starch and sucrose metabolism 1.87 8.05e-3 25/36 (69.44%) MGAM;GBA3;PYGL;...
Graft-versus-host disease 1.87 7.16e-3 32/42 (76.19%) HLA-DQA1;HLA-DPB1;IL1B;...
Fructose and mannose metabolism 1.83 1.03e-2 30/33 (90.91%) FBP1;PFKL;AKR1B1;...
Galactose metabolism 1.80 1.64e-2 26/31 (83.87%) PFKL;AKR1B1;MGAM;...
Histidine metabolism 1.76 2.68e-2 16/22 (72.73%) ALDH2;AOC1;HNMT;...
Ascorbate and aldarate metabolism 1.76 2.48e-2 15/30 (50%) ALDH2;UGT2A3;AKR1A1;...
Glycolysis / Gluconeogenesis 1.75 2.67e-2 56/67 (83.58%) ALDH2;FBP1;PFKL;...
Leishmaniasis 1.73 3.09e-2 67/77 (87.01%) MARCKSL1;TLR4;HLA-DQA1;...
Type I diabetes mellitus 1.73 2.98e-2 38/43 (88.37%) HLA-DQA1;HLA-DPB1;IL1B;...
Pentose phosphate pathway 1.72 3.26e-2 25/30 (83.33%) FBP1;PFKL;TKT;...
One carbon pool by folate 1.70 4.08e-2 15/20 (75%) AMT;MTR;FTCD;...
Complement and coagulation cascades -1.73 4.51e-2 76/85 (89.41%) CFD;FGG;F13A1;...
Parkinson disease -1.79 2.85e-2 176/249 (70.68%) GNAL;PSMD11;DRD2;...
Thermogenesis -1.79 3.38e-2 173/232 (74.57%) ATP5F1C;NDUFAF1;CNR1;...
Non-alcoholic fatty liver disease -1.79 4.51e-2 126/155 (81.29%) PIK3CA;ITCH;COX6C;...
Retrograde endocannabinoid signaling -1.84 3.56e-2 118/148 (79.73%) GNG5;NDUFB11;ABHD6;...
Oxidative phosphorylation -2.35 0.00e+0 93/133 (69.92%) COX7C;CYC1;NDUFB11;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H