General Information of Drug (ID: DMZ1ZQG)

Drug Name
Secalciferol Drug Info
Synonyms Osteo d (TN)
Cross-matching ID
PubChem CID
5283748
ChEBI ID
CHEMBL28818
CAS Number
CAS 55721-11-4
TTD Drug ID
D02ZGI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Butanoate metabolism -1.61 4.66e-2 23/28 (82.14%) HMGCL;OXCT2;BDH2;...
Pyruvate metabolism -1.61 4.85e-2 41/47 (87.23%) ACYP2;DLD;ACAT1;...
Steroid biosynthesis -1.63 4.29e-2 19/20 (95%) LSS;EBP;HSD17B7;...
Parkinson disease -1.65 3.84e-2 176/249 (70.68%) SDHA;CALML4;PSMA7;...
Rheumatoid arthritis -1.65 3.79e-2 78/93 (83.87%) CSF2;MMP1;ATP6V1C1;...
Fluid shear stress and atherosclerosis -1.68 2.85e-2 123/139 (88.49%) RAC3;MAP2K6;HMOX1;...
Glycine, serine and threonine metabolism -1.72 2.31e-2 31/40 (77.5%) PIPOX;PHGDH;GAMT;...
Pentose and glucuronate interconversions -1.74 2.25e-2 17/34 (50%) AKR1B1;UGDH;RPE;...
Galactose metabolism -1.75 2.31e-2 26/31 (83.87%) GLB1;LCT;UGP2;...
PPAR signaling pathway -1.75 2.30e-2 66/74 (89.19%) MMP1;CPT1A;PPARD;...
Valine, leucine and isoleucine degradation -1.76 2.46e-2 42/48 (87.5%) ACAA2;HMGCL;OXCT2;...
Glutathione metabolism -1.76 2.55e-2 43/57 (75.44%) GSTP1;IDH1;ODC1;...
Terpenoid backbone biosynthesis -1.79 1.55e-2 18/22 (81.82%) PMVK;PCYOX1;MVD;...
Collecting duct acid secretion -1.81 1.49e-2 22/27 (81.48%) ATP6V0A4;ATP6V1G1;ATP4A;...
Fructose and mannose metabolism -1.81 1.62e-2 30/33 (90.91%) TPI1;TKFC;ENOSF1;...
Lysosome -1.85 9.51e-3 115/128 (89.84%) HEXA;HYAL2;CTSG;...
Vitamin digestion and absorption -1.86 1.06e-2 17/24 (70.83%) SLC19A3;SLC5A6;PNLIP;...
Fat digestion and absorption -1.88 1.04e-2 35/43 (81.4%) ACAT1;PNLIPRP1;CLPS;...
Glycosaminoglycan degradation -1.89 1.02e-2 19/19 (100%) IDUA;HEXA;HYAL2;...
Citrate cycle (TCA cycle) -1.91 7.92e-3 30/30 (100%) IDH3G;ACO2;SDHC;...
Arginine biosynthesis -1.94 7.13e-3 17/22 (77.27%) ARG1;NOS3;CPS1;...
Proximal tubule bicarbonate reclamation -1.94 8.92e-3 21/23 (91.3%) ATP1B3;PCK2;ATP1A3;...
Mineral absorption -2.02 7.92e-3 48/60 (80%) FTL;ATP1B3;ATP1A3;...
Oxidative phosphorylation -2.13 0.00e+0 93/133 (69.92%) ATP4B;COX6C;SDHC;...
Vibrio cholerae infection -2.26 0.00e+0 44/50 (88%) KDELR2;PRKCA;ATP6V1C1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 1.11uM 6H