Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ2XAP)

Drug Name
LX-1031 Drug Info
Synonyms LG-103; LP-389924; LP-507518; LP-533401; LP-615819; TPH inhibitor (IBS), Lexicon; Tryptophan 5-hydroxylase inhibitor(IBS), Lexicon
Cross-matching ID
PubChem CID
23633604
ChEBI ID
CHEMBL4303338
CAS Number
CAS 945976-76-1
TTD Drug ID
D0H9WR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.05 8.96e-3 80/88 (90.91%) RELN;THBS1;THBS2;...
Antigen processing and presentation -1.79 2.97e-2 60/78 (76.92%) KIR2DL3;NFYA;CTSS;...
Type I diabetes mellitus -1.90 3.65e-3 38/43 (88.37%) FAS;HLA-DOA;HLA-DQB1;...
Hematopoietic cell lineage -1.91 4.38e-3 90/99 (90.91%) IL11RA;KITLG;CD3G;...
Graft-versus-host disease -1.95 0.00e+0 32/42 (76.19%) FAS;HLA-DOA;HLA-DQB1;...
Autoimmune thyroid disease -2.00 0.00e+0 46/53 (86.79%) FAS;HLA-DOA;HLA-DQB1;...
Allograft rejection -2.03 0.00e+0 32/38 (84.21%) FAS;HLA-DOA;HLA-DQB1;...
Primary immunodeficiency -2.22 0.00e+0 33/38 (86.84%) CD79A;CD19;BTK;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H