Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ30AM)

• Drug Name: S-Isopropyl-Isothiourea Drug Info
• Synonyms: S-Isopropylisothiourea hydrobromide; 4269-97-0; S-Isopropylthiourea hydrobromide; 57200-31-4; SR-01000597878; IPITU hydrobromide; C4H10N2S.HBr; S-Isopropylthiuronium bromide; S-Isopropyl-ITU hydrobromide; SCHEMBL7532633; S-ISOPROPYLISOTHIOUREA HBR; DTXSID10431048; MolPort-003-937-638; 2036AH; AKOS024458684; ACM4269970; B6494; SR-01000597878-2
• Cross-matching ID:
  PubChem CID: 445319
  ChEBI ID: CHEMBL483091
  CAS Number: CAS 6913-17-3
  TTD Drug ID: D0J1LO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Malaria	1.97	0.00e+0	44/50 (88%)	THBS1;CCL2;VCAM1;...
p53 signaling pathway	1.92	9.58e-3	63/73 (86.3%)	THBS1;GADD45A;SFN;...
Cysteine and methionine metabolism	-1.74	4.17e-2	43/50 (86%)	KYAT1;MPST;TST;...
Proximal tubule bicarbonate reclamation	-1.77	3.96e-2	21/23 (91.3%)	ATP1B1;AQP1;ATP1B2;...
Other glycan degradation	-1.77	4.95e-2	13/18 (72.22%)	MAN2B2;NEU3;HEXA;...
Selenocompound metabolism	-1.82	4.87e-2	11/17 (64.71%)	SEPHS2;KYAT1;TXNRD1;...
Sulfur metabolism	-1.92	1.56e-2	9/10 (90%)	MPST;TST;PAPSS2;...
Protein processing in endoplasmic reticulum	-2.14	0.00e+0	127/171 (74.27%)	ERO1B;P4HB;RPN2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲