Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZ36RN)

• Drug Name: Mazindol Drug Info
• Synonyms: mazindol; Mazanor; Sanorex; Teronac; Mazildene; 22232-71-9; Magrilon; Dimagrir; Mazindolum; Mazindole; Mazindolum [INN-Latin]; Terenac; AN 448; Mazindol [USAN:BAN:INN]; SAH 42548; CCRIS 3152; DEA No 1605; 5-(4-Chlorophenyl)-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol; 5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol; HSDB 3112; SA 42-548; 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole; EINECS 244-857-0; S 42548; CHEMBL781; 5-p-Chlorophenyl-2,3-dihydro-5H-imidazo(2,1-a)isoindol-5-ol; BRN 0546547; Diestet; Sanjorex; Solucaps; Teronak; Mazindol Medix Brand; Mazindol Novartis Brand; Mazindol Searle Brand; Mazindol Wyeth Brand; Medix Brand of Mazindol; Novartis Brand of Mazindol; Searle Brand of Mazindol; Wyeth Brand of Mazindol; AN 448;AN448; AN-448; Mazanor (TN); SANOREX (TN); Sanorex (TN); Mazindol (JAN/USP/INN); (+-)-5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol; 5-(4-Chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo(2,1-a)isoindole; 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol; 5-(p-Chlorophenyl)-2,5-dihydro-3H-imidazo(2,1-a)isoindol-5-ol; 5H-Imidazo(2,1-a)isoindol-5-ol, 5-(4-chlorophenyl)-2,3-dihydro; [3H]mazindol
• Therapeutic Class: Central Nervous System Stimulants
• Cross-matching ID:
  PubChem CID: 4020
  ChEBI ID: CHEMBL6702
  CAS Number: CAS 22232-71-9
  TTD Drug ID: D0H8QL
  VARIDT Drug ID: DR00850

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Drug metabolism	2.16	0.00e+0	78/151 (51.66%)	GSTM3;ADH1C;NAT1;...
Metabolism of xenobiotics by cytochrome P450	2.13	0.00e+0	49/77 (63.64%)	GSTM3;AKR1C1;ADH1C;...
Steroid hormone biosynthesis	2.01	0.00e+0	43/61 (70.49%)	AKR1C3;AKR1C1;HSD17B2;...
Ovarian steroidogenesis	1.96	2.56e-3	41/51 (80.39%)	AKR1C3;HSD17B2;BMP6;...
Folate biosynthesis	1.89	8.20e-3	23/26 (88.46%)	AKR1C3;AKR1B10;ALPL;...
Pentose and glucuronate interconversions	1.88	1.02e-2	17/34 (50%)	AKR1B10;UGT2B15;UGT2B28;...
Propanoate metabolism	1.87	1.02e-2	30/34 (88.24%)	ACAT2;EHHADH;ABAT;...
Complement and coagulation cascades	1.86	1.15e-2	76/85 (89.41%)	TFPI;THBD;CFH;...
Caffeine metabolism	1.85	1.14e-2	5/6 (83.33%)	NAT1;NAT2;CYP1A2;...
Linoleic acid metabolism	1.84	1.02e-2	21/29 (72.41%)	PLA2G2A;CYP2C9;PLAAT3;...
Arachidonic acid metabolism	1.84	1.02e-2	48/61 (78.69%)	AKR1C3;GPX2;GPX3;...
Mismatch repair	1.83	1.02e-2	22/23 (95.65%)	PCNA;MLH1;RPA3;...
Retinol metabolism	1.79	1.58e-2	41/68 (60.29%)	ADH1C;DHRS9;UGT2B15;...
Butanoate metabolism	1.78	1.83e-2	23/28 (82.14%)	HMGCS2;ACAT2;EHHADH;...
Legionellosis	1.77	1.84e-2	51/57 (89.47%)	HSPA6;CXCL2;CASP1;...
Synthesis and degradation of ketone bodies	1.76	1.86e-2	9/10 (90%)	HMGCS2;ACAT2;BDH2;...
DNA replication	1.73	2.29e-2	34/36 (94.44%)	PCNA;RPA3;RFC5;...
Mineral absorption	1.73	2.16e-2	48/60 (80%)	MT1E;MT1F;MT1H;...
Glyoxylate and dicarboxylate metabolism	1.70	2.91e-2	23/30 (76.67%)	ACAT2;SHMT1;GLDC;...
Phenylalanine metabolism	1.68	3.23e-2	14/17 (82.35%)	GLYAT;PAH;HPD;...
Renin secretion	1.63	4.93e-2	61/69 (88.41%)	AQP1;GNAI1;CALML4;...
Hematopoietic cell lineage	-1.94	9.70e-3	90/99 (90.91%)	GP1BA;FLT3LG;KIT;...
Primary immunodeficiency	-1.99	9.70e-3	33/38 (86.84%)	CD8B;IL7R;IL2RG;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼