Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZASMP)

• Drug Name: LY2784544 Drug Info
• Synonyms: LY2784544; 1229236-86-5; GANDOTINIB; LY 2784544; LY-2784544; Gandotinib (LY2784544); UNII-ANC71R916O; LY2784544(Gandotinib); ANC71R916O; 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine; C23H25ClFN7O; 3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine; 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
• Cross-matching ID:
  PubChem CID: 46213929
  ChEBI ID: CHEMBL2107823
  CAS Number: CAS 1229236-86-5
  TTD Drug ID: D05TSJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proteasome	1.97	3.88e-2	44/46 (95.65%)	PSMA7;PSMA5;PSMA3;...
TNF signaling pathway	1.86	3.88e-2	103/112 (91.96%)	VCAM1;MMP9;CCL2;...
Mineral absorption	1.85	3.56e-2	48/60 (80%)	STEAP1;TF;SLC26A3;...
Riboflavin metabolism	1.84	2.85e-2	7/8 (87.5%)	ACP1;ACP5;RFK;...
Parkinson disease	1.81	3.45e-2	176/249 (70.68%)	PRKACB;BAX;PSMA7;...
Steroid hormone biosynthesis	1.80	2.96e-2	43/61 (70.49%)	UGT2B28;HSD17B2;CYP3A7;...
Ferroptosis	1.80	2.59e-2	36/41 (87.8%)	TFRC;SLC39A8;TF;...
Pentose and glucuronate interconversions	1.78	2.73e-2	17/34 (50%)	UGT2B28;SORD;UGT2B15;...
Folate biosynthesis	1.73	4.79e-2	23/26 (88.46%)	GCH1;PAH;GGH;...
IL-17 signaling pathway	1.73	4.35e-2	84/94 (89.36%)	CXCL8;MMP9;CCL2;...
Notch signaling pathway	-1.98	6.72e-3	49/59 (83.05%)	DTX3;DTX4;TLE6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼