Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZC90K)

• Drug Name: Vitamin E Drug Info
• Synonyms: Covi-ox; VITAMIN E; E-Vimin; Syntopherol; Profecundin; Evitaminum; Viprimol; Vascuals; Etamican; Viteolin; Tokopharm; Vitayonon; Epsilan; Emipherol; Denamone; Almefrol; Verrol; Ilitia; Etavit; 77171-98-3; Evion; Esorb; alpha-Tokoferol; alpha Tocopherol; Vitaplex E; Vitamin E alpha; Eprolin S; Viterra E; E Prolin; Spavit E; Vita E; Endo E; Med-E; Lan-E; Antisterility vitamin; alpha-Tocopherol acid; Tenox GT 1; (R)-2,5,7,8-tetramethyl-2-((4S,8S)-4,8,12-trimethyltridecyl)chroman-6-ol; Rhenogran Ronotec 50; Vi-E; Covitol F 1000; E 307 (tocopherol)
• Cross-matching ID:
  PubChem CID: 14985
  ChEBI ID: CHEMBL47
  CAS Number: CAS 59-02-9
  TTD Drug ID: D02TQO
  INTEDE Drug ID: DR1701

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cell cycle	1.84	3.86e-2	110/124 (88.71%)	PLK1;CCNA2;TGFB3;...
Autoimmune thyroid disease	-1.73	4.42e-2	46/53 (86.79%)	HLA-DPB1;TSHB;IL5;...
Vibrio cholerae infection	-1.73	4.87e-2	44/50 (88%)	KDELR1;TJP1;ATP6V0A1;...
Longevity regulating pathway	-1.75	4.60e-2	90/151 (59.6%)	PIK3CD;INS;PRKACB;...
Type I diabetes mellitus	-1.78	3.48e-2	38/43 (88.37%)	HLA-DRA;INS;ICA1;...
Antigen processing and presentation	-1.79	3.65e-2	60/78 (76.92%)	HLA-DRA;HLA-DQA1;B2M;...
Rheumatoid arthritis	-1.83	3.16e-2	78/93 (83.87%)	CXCL6;CSF2;HLA-DPB1;...
Protein processing in endoplasmic reticulum	-1.84	3.35e-2	127/171 (74.27%)	STUB1;CAPN1;EIF2AK1;...
Allograft rejection	-1.87	4.46e-2	32/38 (84.21%)	HLA-DPB1;IL5;HLA-DRA;...
Legionellosis	-1.88	4.87e-2	51/57 (89.47%)	NFKB2;SAR1B;CXCL3;...
Graft-versus-host disease	-2.07	0.00e+0	32/42 (76.19%)	HLA-DRA;HLA-DQA1;IL6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.002uM - 10uM	6H, 24H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.002uM - 10uM	6H	Hide ▲

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.002uM - 10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.002uM - 10uM	6H, 24H	Show ▼