Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZD0NA)

• Drug Name: torin 1 Drug Info
• Synonyms: Torin-1
• Cross-matching ID:
  PubChem CID: 49836027
  ChEBI ID: CHEMBL1256459
  CAS Number: CAS 1222998-36-8
  TTD Drug ID: D0H0HR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
ECM-receptor interaction	2.27	0.00e+0	80/88 (90.91%)	ITGB5;LAMC2;COL9A2;...
Ribosome	2.13	0.00e+0	113/158 (71.52%)	RPL36;RPL14;RPL10A;...
Notch signaling pathway	1.79	4.64e-2	49/59 (83.05%)	HES1;TLE1;NCOR2;...
Malaria	1.79	3.48e-2	44/50 (88%)	MET;IL1B;IL18;...
Butanoate metabolism	-1.76	6.51e-3	23/28 (82.14%)	ACAT1;OXCT1;GAD2;...
Vibrio cholerae infection	-1.77	5.97e-3	44/50 (88%)	ATP6V0C;ATP6V1B2;PRKACB;...
Ferroptosis	-1.77	6.17e-3	36/41 (87.8%)	GSS;ALOX15;ACSL4;...
Citrate cycle (TCA cycle)	-1.77	6.38e-3	30/30 (100%)	SDHA;PDHA1;PDHB;...
Glycine, serine and threonine metabolism	-1.77	6.20e-3	31/40 (77.5%)	BHMT;SHMT2;PIPOX;...
Spinocerebellar ataxia	-1.77	6.43e-3	128/143 (89.51%)	PIK3R1;PSMD8;GRIA2;...
Pentose and glucuronate interconversions	-1.78	6.67e-3	17/34 (50%)	UGP2;RPE;UGT2B4;...
Huntington disease	-1.79	6.94e-3	233/306 (76.14%)	SDHD;NDUFA9;KLC2;...
Drug metabolism	-1.79	7.23e-3	78/151 (51.66%)	FMO1;GSTM5;ADH5;...
Pyruvate metabolism	-1.81	6.61e-3	41/47 (87.23%)	LDHA;ADH1B;ACAT1;...
Fatty acid elongation	-1.81	6.36e-3	19/27 (70.37%)	ECHS1;HACD3;HSD17B12;...
Mineral absorption	-1.81	6.70e-3	48/60 (80%)	ATP1B2;MT1G;SLC34A2;...
Valine, leucine and isoleucine degradation	-1.88	3.21e-3	42/48 (87.5%)	ECHS1;DLD;ALDH2;...
Fructose and mannose metabolism	-1.91	6.81e-4	30/33 (90.91%)	PFKFB3;KHK;FPGT;...
Amyotrophic lateral sclerosis	-1.97	0.00e+0	267/364 (73.35%)	SDHD;NUP50;NDUFA9;...
Glycolysis / Gluconeogenesis	-1.97	0.00e+0	56/67 (83.58%)	LDHA;ENO3;ADH1B;...
Metabolism of xenobiotics by cytochrome P450	-1.99	0.00e+0	49/77 (63.64%)	GSTM5;ADH5;CYP2C9;...
Fatty acid degradation	-2.02	0.00e+0	40/43 (93.02%)	ACADM;ADH1A;EHHADH;...
Bile secretion	-2.03	0.00e+0	68/90 (75.56%)	SLCO1B3;BAAT;ABCC2;...
Prion disease	-2.05	0.00e+0	209/273 (76.56%)	KIF5B;NDUFV2;C8B;...
Terpenoid backbone biosynthesis	-2.09	0.00e+0	18/22 (81.82%)	PDSS2;PCYOX1;MVD;...
Protein processing in endoplasmic reticulum	-2.09	0.00e+0	127/171 (74.27%)	SEC24C;MAPK10;DDIT3;...
Steroid hormone biosynthesis	-2.16	0.00e+0	43/61 (70.49%)	SULT2B1;CYP3A5;CYP3A7;...
PPAR signaling pathway	-2.17	0.00e+0	66/74 (89.19%)	APOA2;CPT2;ACSL4;...
Parkinson disease	-2.20	0.00e+0	176/249 (70.68%)	PARK7;KIF5B;SNCAIP;...
Oxidative phosphorylation	-2.21	0.00e+0	93/133 (69.92%)	NDUFV2;ATP5PD;SDHD;...
Biosynthesis of unsaturated fatty acids	-2.22	0.00e+0	21/27 (77.78%)	HSD17B4;HACD3;HSD17B12;...
Folate biosynthesis	-2.36	0.00e+0	23/26 (88.46%)	QDPR;SPR;PTS;...
Proteasome	-2.39	0.00e+0	44/46 (95.65%)	PSMD7;PSMB9;PSMC6;...
Steroid biosynthesis	-2.46	0.00e+0	19/20 (95%)	LIPA;TM7SF2;LBR;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Chronic myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HAP1	CVCL_Y019	Homo sapiens	0.66uM - 3.33uM	24H	Hide ▲
HAP1 BRD4 (-) 1	CVCL_SF59	Homo sapiens	0.66uM - 3.33uM	24H	Hide ▲
HAP1 CDK4 (-) 1	CVCL_SI36	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 HDAC5 (-) 1	CVCL_SR11	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 ITGA4 (-) 1	CVCL_ST27	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 MAPK8 (-) 1	CVCL_SW99	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 PIK3CA (-) 1	CVCL_TD60	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 PRKACA (-) 1	CVCL_TG70	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 PRKCQ (-)	CVCL_TG92	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 RELA (-) 1	CVCL_TI75	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 SRC (-) 1	CVCL_TQ36	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼
HAP1 TP53 (-) 1	CVCL_RJ70	Homo sapiens	0.66uM - 3.33uM	24H	Show ▼

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H	Show ▼
MDA-MB-231	CVCL_0062	Homo sapiens	0.0005uM - 10uM	3H, 6H, 24H	Show ▼
SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼
Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Normal (Epithelial)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HME1	CVCL_2950	Homo sapiens	0.0001uM - 10uM	3H, 24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	2H, 6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HL-60	CVCL_0002	Homo sapiens	0.01uM - 1.11uM	2H, 24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
LNCaP	CVCL_0395	Homo sapiens	0.04uM - 10uM	3H, 24H	Show ▼
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼