Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZD5QR)

Drug Name
Cytarabine Drug Info
Synonyms
Alexan; AraC; Arabinocytidine; Arabinofuranosylcytosine; Arabinosylcytosine; Arabitin; Aracytidine; Aracytin; Aracytine; Arafcyt; Citarabina; Cytarabin; Cytarabina; Cytarabinoside; Cytarabinum; Cytarbel; Cytonal; Cytosar; Cytosinearabinoside; DepoCyte; Depocyt; Erpalfa; Iretin; Spongocytidine; Tarabine; Udicil; Arabinosyl Cytosine; Cytarabine liposome injection; Cytosine arabinofuranoside; Cytosine arabinose; Cytosine arabinoside; AR3; BTB15125; CHX 3311; U 19920A; Ara-C; Ara-Cytidine; Beta-Ara C; Beta-Arabinosylcytosine; Beta-cytosine arabinoside; Citarabina [INN-Spanish]; Cytarabinum [INN-Latin]; Cytosar-U; Cytosine arabinoside (VAN); Depocyt (TN); Depocyt (liposomal); Intrathecal (injected into the spinal fluid) DepoCyt; U-19920; Beta-D-Arabinosylcytosine; Cytosar-U (TN); Cytosine beta-D-arabinofuranoside; Cytosine beta-D-arabinofuranoside hydrochloride; Cytosine beta-D-arabinoside; Cytosine-beta-arabinoside; Intrathecal cytarabine (also known as ara-C); U-19,920; CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9); Cytarabine (JP15/USP/INN); Cytarabine [USAN:INN:BAN:JAN]; Cytosine 1-beta-D-arabinofuranoside; Cytosine, beta-D-arabinoside; Cytosine-beta-D-arabinofuranoside; Cytosine-1-beta-D-arabinofuranoside; Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine; (beta-D-Arabinofuranosyl)cytosine; 1-.beta.-D-arabinofuranosyl-cytosine; 1-Arabinofuranosylcytosine; 1-beta-D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosylcytosine; 1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside; 1-beta-D-Arabinosylcytosine; 1beta-Arabinofuranasylcytosine; 1beta-D-Arabinofuranosylcytosine; 1beta-D-Arabinosylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-D-arabinofuranosyl-[CAS]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
6253
ChEBI ID
CHEMBL803
CAS Number
CAS 147-94-4
TTD Drug ID
D07XSN
VARIDT Drug ID
DR00416
INTEDE Drug ID
DR0398
ACDINA Drug ID
D00976

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
p53 signaling pathway 2.40 0.00e+0 63/73 (86.3%) CDKN1A;DDB2;RRM2;...
DNA replication 2.39 0.00e+0 34/36 (94.44%) RFC4;MCM5;RNASEH2A;...
Graft-versus-host disease 2.22 0.00e+0 32/42 (76.19%) FAS;HLA-B;HLA-F;...
Mismatch repair 2.05 0.00e+0 22/23 (95.65%) RFC4;RPA3;RFC5;...
Epstein-Barr virus infection 1.99 2.19e-3 189/202 (93.56%) CDKN1A;DDB2;CXCL10;...
Glutathione metabolism 1.97 1.82e-3 43/57 (75.44%) RRM2;GSTM3;ANPEP;...
Type I diabetes mellitus 1.97 1.56e-3 38/43 (88.37%) FAS;HLA-B;HLA-F;...
Pyrimidine metabolism 1.97 1.37e-3 40/56 (71.43%) RRM2;UPP1;TYMS;...
Homologous recombination 1.93 2.43e-3 35/41 (85.37%) BRCA1;RPA3;RAD51;...
Nucleotide excision repair 1.92 2.19e-3 40/47 (85.11%) DDB2;RFC4;RPA3;...
Small cell lung cancer 1.89 1.99e-3 90/92 (97.83%) CDKN1A;DDB2;GADD45A;...
Drug metabolism 1.89 1.82e-3 78/151 (51.66%) RRM2;GSTM3;NAT1;...
Influenza A 1.86 3.36e-3 156/172 (90.7%) TNFRSF10B;TNFSF10;CXCL10;...
Viral myocarditis 1.85 3.90e-3 53/60 (88.33%) HLA-B;HLA-F;HLA-C;...
Viral protein interaction with cytokine and cytokine re... 1.84 5.10e-3 84/100 (84%) CXCL14;TNFRSF10B;TNFSF10;...
TNF signaling pathway 1.80 1.02e-2 103/112 (91.96%) CXCL10;FAS;BIRC3;...
Rheumatoid arthritis 1.77 1.74e-2 78/93 (83.87%) CCL5;CXCL12;CCL2;...
Allograft rejection 1.77 1.64e-2 32/38 (84.21%) FAS;HLA-B;HLA-F;...
Glycine, serine and threonine metabolism 1.77 1.61e-2 31/40 (77.5%) GATM;PGAM1;MAOB;...
Staphylococcus aureus infection 1.76 1.75e-2 72/95 (75.79%) KRT14;KRT17;KRT13;...
Cell cycle 1.74 1.77e-2 110/124 (88.71%) CDKN1A;CDK1;GADD45A;...
ECM-receptor interaction 1.74 1.79e-2 80/88 (90.91%) ITGAV;LAMB3;COL6A1;...
Malaria 1.73 1.81e-2 44/50 (88%) THBS2;CCL2;CXCL8;...
Fanconi anemia pathway 1.72 2.05e-2 36/54 (66.67%) BRCA1;FANCI;RPA3;...
Metabolism of xenobiotics by cytochrome P450 1.71 2.23e-2 49/77 (63.64%) GSTM3;GSTP1;GSTO1;...
NF-kappa B signaling pathway 1.69 2.44e-2 90/104 (86.54%) GADD45A;BIRC3;RELB;...
Phagosome 1.68 2.47e-2 118/152 (77.63%) TUBB2A;HLA-B;HLA-F;...
Butanoate metabolism 1.68 2.61e-2 23/28 (82.14%) ABAT;ALDH5A1;BDH1;...
Measles 1.68 2.56e-2 133/139 (95.68%) MX1;FAS;OAS1;...
Arachidonic acid metabolism 1.67 2.84e-2 48/61 (78.69%) AKR1C3;CBR3;PTGS2;...
Spliceosome -1.80 1.82e-2 101/150 (67.33%) SRSF4;DDX46;SNRNP70;...
RNA transport -1.89 1.25e-2 128/186 (68.82%) MAGOH;THOC6;SUMO4;...
Aminoacyl-tRNA biosynthesis -1.92 9.77e-3 15/66 (22.73%) WARS2;TARS2;DARS2;...
Ether lipid metabolism -1.95 7.81e-3 32/49 (65.31%) PAFAH1B3;PLAAT3;PLA2G5;...
Ribosome biogenesis in eukaryotes -2.03 7.81e-3 52/108 (48.15%) IMP3;SNU13;MPHOSPH10;...
mRNA surveillance pathway -2.30 0.00e+0 71/98 (72.45%) PPP2R2D;CSTF2T;NXT2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Normal (Stromal)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HS-27a CVCL_0313 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SKM-1 CVCL_0010 Homo sapiens 10uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H