Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZE2JO)

Drug Name
SNS-595 Drug Info
Synonyms
Voreloxin; Vosaroxin; AG 7352; SNS 595; SPC 595; AG 7352 (TN); AG-7352; SNS 595 (TN); SPC 595 (TN); SPC-595; Voreloxin (TN); Voreloxin (USAN); SNS-595 (TN); 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
Cross-matching ID
PubChem CID
9952884
CAS Number
CAS 175414-77-4
TTD Drug ID
D00NVM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.26 0.00e+0 93/133 (69.92%) NDUFB1;ATP5PD;COX6B1;...
Ribosome 2.04 0.00e+0 113/158 (71.52%) MRPS16;RPL36;RPS25;...
Bladder cancer 1.96 3.38e-3 40/41 (97.56%) E2F2;FGFR3;CXCL8;...
Parkinson disease 1.88 1.52e-2 176/249 (70.68%) TUBB2A;UCHL1;NDUFB1;...
Metabolism of xenobiotics by cytochrome P450 1.80 3.44e-2 49/77 (63.64%) GSTP1;ADH5;ALDH3A1;...
Diabetic cardiomyopathy 1.79 3.04e-2 162/203 (79.8%) GAPDH;NDUFB1;ATP5PD;...
Huntington disease 1.78 2.60e-2 233/306 (76.14%) TUBB2A;NDUFB1;ATP5PD;...
Glycolysis / Gluconeogenesis 1.78 2.40e-2 56/67 (83.58%) GAPDH;PGAM1;PFKL;...
Primary bile acid biosynthesis 1.77 2.48e-2 15/17 (88.24%) AMACR;SCP2;CYP7A1;...
Non-alcoholic fatty liver disease 1.76 2.53e-2 126/155 (81.29%) CXCL8;NDUFB1;COX6B1;...
Thermogenesis 1.75 2.58e-2 173/232 (74.57%) NDUFB1;ATP5PD;CNR1;...
Amyotrophic lateral sclerosis 1.73 2.95e-2 267/364 (73.35%) TUBB2A;NDUFB1;ANXA11;...
Retinol metabolism 1.72 2.96e-2 41/68 (60.29%) ADH5;ADH1C;DHRS3;...
Histidine metabolism 1.67 4.56e-2 16/22 (72.73%) HNMT;ALDH3A1;AOC1;...
Intestinal immune network for IgA production -2.01 0.00e+0 38/48 (79.17%) HLA-DRA;IL15;TNFRSF17;...
Asthma -2.10 0.00e+0 25/31 (80.65%) MS4A2;CCL11;EPX;...
Systemic lupus erythematosus -2.14 0.00e+0 45/135 (33.33%) HLA-DRA;CTSG;HLA-DPB1;...
Staphylococcus aureus infection -2.19 0.00e+0 72/95 (75.79%) FCGR2C;FCGR2B;ITGAM;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H