Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZFIGQ)

Drug Name
TG02 Drug Info
Synonyms
SB1317; 937270-47-8; TG02; TG-02; TG02 (Double bond Z/E); UNII-40D08182TT; CHEMBL1944698; 40D08182TT; SB-1317; 1204918-72-8; C23H24N4O; Tube011; SB-1317 free base; TG02 (Double bond E); TG02 [WHO-DD]; SCHEMBL823947; SCHEMBL2298965; GTPL9095; SCHEMBL17595943; EX-A239; MolPort-039-139-793; AOB87361; BCP07033; ZINC68251500; BDBM50363196; 4029AH; AKOS030527020; AKOS032950000; SB1317(TG-02); SB14606; CS-0884; compound 26h [PMID: 22148278]; KB-80503; HY-15166; W-5884
Cross-matching ID
PubChem CID
16739650
ChEBI ID
CHEMBL1944698
CAS Number
CAS 1204918-72-8
TTD Drug ID
D0P0KN
INTEDE Drug ID
DR1818

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.34 0.00e+0 80/88 (90.91%) LAMB2;VWF;THBS4;...
Citrate cycle (TCA cycle) 2.13 0.00e+0 30/30 (100%) DLD;ACO1;ACO2;...
Oxidative phosphorylation 2.04 0.00e+0 93/133 (69.92%) TCIRG1;COX17;ATP6AP1;...
Focal adhesion 1.97 3.44e-3 180/201 (89.55%) CAV1;LAMB2;VWF;...
Fatty acid elongation 1.94 2.75e-3 19/27 (70.37%) ACOT7;PPT1;HACD1;...
Fructose and mannose metabolism 1.89 4.59e-3 30/33 (90.91%) PFKM;AKR1B1;SORD;...
Starch and sucrose metabolism 1.81 1.38e-2 25/36 (69.44%) GPI;PYGL;HK1;...
Lysosome 1.79 1.72e-2 115/128 (89.84%) CTSZ;LAPTM4B;CTSC;...
AGE-RAGE signaling pathway in diabetic complications 1.77 1.84e-2 97/100 (97%) EGR1;MMP2;COL4A1;...
Diabetic cardiomyopathy 1.77 1.79e-2 162/203 (79.8%) MMP9;MMP2;PRKCZ;...
Galactose metabolism 1.74 2.63e-2 26/31 (83.87%) PFKM;AKR1B1;HK1;...
Glycolysis / Gluconeogenesis 1.73 2.52e-2 56/67 (83.58%) PFKM;DLD;GPI;...
Retrograde endocannabinoid signaling 1.73 2.33e-2 118/148 (79.73%) MGLL;GABRE;ITPR3;...
PPAR signaling pathway 1.72 2.75e-2 66/74 (89.19%) LPL;HMGCS2;ADIPOQ;...
Valine, leucine and isoleucine degradation 1.71 2.66e-2 42/48 (87.5%) HMGCS2;DLD;OXCT1;...
Pentose phosphate pathway 1.69 3.18e-2 25/30 (83.33%) PFKM;GPI;RPIA;...
Glutathione metabolism 1.69 3.08e-2 43/57 (75.44%) GSTM3;SRM;LAP3;...
Phagosome 1.69 2.98e-2 118/152 (77.63%) THBS4;HLA-DQA1;TCIRG1;...
Glycosaminoglycan degradation 1.68 3.19e-2 19/19 (100%) GALNS;HYAL1;SGSH;...
Dilated cardiomyopathy 1.67 3.44e-2 86/96 (89.58%) SGCB;ITGAV;ITGA6;...
Relaxin signaling pathway 1.65 4.46e-2 114/129 (88.37%) MMP9;MMP2;COL4A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H