Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZHOYM)

Drug Name
SDZ-PCO-400 Drug Info
Synonyms PCO-400
Cross-matching ID
PubChem CID
129348
ChEBI ID
CHEMBL92920
CAS Number
CAS 121055-10-5
TTD Drug ID
D0U8IJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.39 0.00e+0 44/46 (95.65%) PSMD11;PSMA4;PSMB3;...
Allograft rejection 2.13 0.00e+0 32/38 (84.21%) HLA-F;GZMB;HLA-DPA1;...
Complement and coagulation cascades 2.13 0.00e+0 76/85 (89.41%) C1S;SERPINA1;SERPINA5;...
Fanconi anemia pathway 2.12 0.00e+0 36/54 (66.67%) CENPX;FANCL;RMI1;...
Systemic lupus erythematosus 2.08 0.00e+0 45/135 (33.33%) C1S;C1R;HLA-DPA1;...
Graft-versus-host disease 2.06 0.00e+0 32/42 (76.19%) HLA-F;GZMB;HLA-DPA1;...
DNA replication 2.02 0.00e+0 34/36 (94.44%) PCNA;MCM6;SSBP1;...
Ribosome 1.99 0.00e+0 113/158 (71.52%) RPS4Y1;RPL10;RPL29;...
Antigen processing and presentation 1.90 0.00e+0 60/78 (76.92%) HLA-F;CD8A;PDIA3;...
Autoimmune thyroid disease 1.89 1.57e-3 46/53 (86.79%) HLA-F;GZMB;HLA-DPA1;...
Staphylococcus aureus infection 1.85 2.15e-3 72/95 (75.79%) C1S;KRT16;KRT14;...
Pyrimidine metabolism 1.85 1.97e-3 40/56 (71.43%) TYMS;CANT1;RRM2;...
Type I diabetes mellitus 1.84 3.63e-3 38/43 (88.37%) PTPRN2;HLA-F;GZMB;...
Cell cycle 1.79 9.00e-3 110/124 (88.71%) PCNA;CDKN1B;CCND2;...
Pertussis 1.75 1.26e-2 64/76 (84.21%) C1S;CD14;C1R;...
Mismatch repair 1.67 3.00e-2 22/23 (95.65%) PCNA;SSBP1;RFC4;...
Protein export 1.62 4.17e-2 17/23 (73.91%) SRP72;SEC61B;HSPA5;...
Vibrio cholerae infection -1.75 3.73e-2 44/50 (88%) PRKCA;PLCG2;TCIRG1;...
Proximal tubule bicarbonate reclamation -1.78 2.77e-2 21/23 (91.3%) ATP1B2;CA4;GLUD2;...
Collecting duct acid secretion -1.83 1.19e-2 22/27 (81.48%) TCIRG1;ATP6V0D1;ATP6V0A4;...
Pancreatic secretion -1.90 5.93e-3 87/102 (85.29%) SCTR;PLCB1;ATP1A1;...
Steroid biosynthesis -2.00 0.00e+0 19/20 (95%) TM7SF2;SOAT1;SQLE;...
Aldosterone-regulated sodium reabsorption -2.00 0.00e+0 34/37 (91.89%) IRS1;ATP1B1;INSR;...
Regulation of lipolysis in adipocytes -2.01 0.00e+0 52/55 (94.55%) ADRB2;CGA;ADCY9;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 15uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H