Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZIM37)

• Drug Name: CP-868596 Drug Info
• Synonyms: Crenolanib; 670220-88-9; Crenolanib (CP-868596); ARO-002; UNII-LQF7I567TQ; LQF7I567TQ; CP-868596 (Crenolanib); CP-868,596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine; 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP868569; 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine; J-502712; 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 10366136
  ChEBI ID: CHEMBL145365
  CAS Number: CAS 670220-88-9
  TTD Drug ID: D0J1GR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.22	0.00e+0	19/20 (95%)	MSMO1;TM7SF2;NSDHL;...
DNA replication	2.12	0.00e+0	34/36 (94.44%)	RPA2;RFC5;RFC3;...
Folate biosynthesis	1.96	2.80e-3	23/26 (88.46%)	MOCOS;AKR1B10;GCH1;...
Cysteine and methionine metabolism	1.95	2.10e-3	43/50 (86%)	KYAT3;PSAT1;CBS;...
Tyrosine metabolism	1.91	1.68e-3	30/36 (83.33%)	ALDH3A1;ADH1B;TYRP1;...
Homologous recombination	1.87	1.40e-3	35/41 (85.37%)	RAD51;RPA2;SEM1;...
Proteasome	1.81	1.20e-2	44/46 (95.65%)	PSMB9;PSMA5;PSMD14;...
Mismatch repair	1.80	1.16e-2	22/23 (95.65%)	RPA2;RFC5;RFC3;...
Nucleotide excision repair	1.79	1.77e-2	40/47 (85.11%)	RAD23B;RPA2;RFC5;...
Glycine, serine and threonine metabolism	1.77	1.93e-2	31/40 (77.5%)	PSAT1;CBS;SDS;...
Tryptophan metabolism	1.72	2.98e-2	35/42 (83.33%)	KYAT3;HADH;ACAT2;...
Fanconi anemia pathway	1.70	3.36e-2	36/54 (66.67%)	FANCI;RAD51;RPA2;...
Pentose and glucuronate interconversions	1.70	3.49e-2	17/34 (50%)	SORD;AKR1B10;UGP2;...
Arginine and proline metabolism	1.64	4.56e-2	39/50 (78%)	CKB;ODC1;ALDH1B1;...
Proteoglycans in cancer	-1.70	4.59e-2	172/205 (83.9%)	PLCG1;PIK3R3;FZD2;...
Regulation of actin cytoskeleton	-1.70	4.94e-2	185/218 (84.86%)	F2R;ITGA2;ARPC1B;...
Renal cell carcinoma	-1.71	4.78e-2	68/69 (98.55%)	PIK3CB;PIK3R3;HGF;...
Rap1 signaling pathway	-1.72	4.17e-2	184/210 (87.62%)	RALA;PDGFA;PIK3CB;...
Inflammatory bowel disease	-1.72	4.59e-2	58/65 (89.23%)	SMAD3;HLA-DQB1;IL18RAP;...
Staphylococcus aureus infection	-1.74	4.20e-2	72/95 (75.79%)	HLA-DPB1;C5AR1;KRT17;...
Prostate cancer	-1.75	3.87e-2	93/97 (95.88%)	PDGFA;PIK3CB;HSP90B1;...
Acute myeloid leukemia	-1.75	4.26e-2	66/67 (98.51%)	SOS1;RUNX1;RPS6KB1;...
Carbohydrate digestion and absorption	-1.82	2.29e-2	37/47 (78.72%)	PIK3CB;PIK3R3;FXYD2;...
MicroRNAs in cancer	-1.83	2.52e-2	146/310 (47.1%)	CASP3;ITGA5;HDAC1;...
Relaxin signaling pathway	-1.83	3.15e-2	114/129 (88.37%)	CREB1;GNB5;TGFBR1;...
Phospholipase D signaling pathway	-1.85	3.44e-2	134/148 (90.54%)	PLCG2;GRM8;TSC1;...
Asthma	-1.94	1.15e-2	25/31 (80.65%)	HLA-DPB1;HLA-DPA1;PRG2;...
Systemic lupus erythematosus	-2.00	1.15e-2	45/135 (33.33%)	CTSG;HLA-DPB1;HLA-DPA1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲