Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZK0FQ)

Drug Name
Oestradiol valerate and dienogest Drug Info
Synonyms
Dienogest; 65928-58-7; Dienogestrel; Dienogestum; Dienogestril; Dinagest; Natazia; Endometrion; Visanne; STS-557; STS 557; Dienogestum [Latin]; UNII-46M3EV8HHE; MJR-35; 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; BAY86-5258; BAY 86-5258; 46M3EV8HHE; CHEBI:70708; 17-alpha-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one; 2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile; 17-alpha-Cyanomethyl-17-beta-hydroxyestra-4,9(10)-diene-3-one; Natazia (TN)
Cross-matching ID
PubChem CID
68861
ChEBI ID
CHEMBL70708
CAS Number
CAS 65928-58-7
TTD Drug ID
D04CBI
INTEDE Drug ID
DR0490

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Type I diabetes mellitus 2.32 0.00e+0 38/43 (88.37%) CPE;HLA-B;HLA-F;...
Allograft rejection 2.24 0.00e+0 32/38 (84.21%) HLA-B;HLA-F;HLA-C;...
Viral myocarditis 2.14 0.00e+0 53/60 (88.33%) HLA-B;HLA-F;HLA-C;...
Autoimmune thyroid disease 2.11 0.00e+0 46/53 (86.79%) HLA-B;HLA-F;HLA-C;...
DNA replication 2.07 0.00e+0 34/36 (94.44%) MCM2;PCNA;MCM4;...
Antigen processing and presentation 2.06 0.00e+0 60/78 (76.92%) HLA-B;HLA-F;HLA-C;...
Graft-versus-host disease 1.99 0.00e+0 32/42 (76.19%) HLA-B;HLA-F;HLA-C;...
Human T-cell leukemia virus 1 infection 1.89 3.02e-3 197/219 (89.95%) CDC20;HLA-B;HLA-F;...
Pentose phosphate pathway 1.86 5.37e-3 25/30 (83.33%) PFKL;PFKP;PGD;...
Acute myeloid leukemia 1.85 7.25e-3 66/67 (98.51%) LEF1;CD14;DUSP6;...
Cell cycle 1.82 1.10e-2 110/124 (88.71%) SMC1A;CDC20;SFN;...
Amoebiasis 1.80 1.21e-2 99/102 (97.06%) LAMC2;COL4A5;LAMA3;...
Herpes simplex virus 1 infection 1.76 2.32e-2 165/498 (33.13%) BST2;HLA-B;HLA-F;...
Systemic lupus erythematosus 1.75 2.59e-2 45/135 (33.33%) CD40;HLA-DPA1;SNRPB;...
Phagosome 1.74 2.42e-2 118/152 (77.63%) HLA-B;HLA-F;HLA-C;...
Mismatch repair 1.71 3.85e-2 22/23 (95.65%) PCNA;RFC2;RFC5;...
Central carbon metabolism in cancer 1.68 4.48e-2 67/70 (95.71%) PFKL;PFKP;PKM;...
Asthma 1.68 4.63e-2 25/31 (80.65%) CD40;HLA-DPA1;HLA-DRA;...
Glucagon signaling pathway 1.67 4.96e-2 89/107 (83.18%) PFKL;PFKP;PLCB1;...
Diabetic cardiomyopathy -1.72 3.81e-2 162/203 (79.8%) ATP2A3;COX5A;GAPDH;...
Huntington disease -1.72 4.15e-2 233/306 (76.14%) PSMD8;NDUFB6;NRF1;...
Ovarian steroidogenesis -1.74 3.78e-2 41/51 (80.39%) PLA2G4C;LHCGR;HSD3B1;...
Retrograde endocannabinoid signaling -1.74 4.39e-2 118/148 (79.73%) NDUFA9;GRIA1;RIMS1;...
Non-alcoholic fatty liver disease -1.83 1.42e-2 126/155 (81.29%) COX5A;BCL2L11;NDUFA9;...
Thermogenesis -1.89 1.18e-2 173/232 (74.57%) ATP5MC3;ATP5PF;RPS6KA6;...
Ribosome -1.89 1.77e-2 113/158 (71.52%) MRPL28;RPL26L1;MRPL33;...
Oxidative phosphorylation -2.52 0.00e+0 93/133 (69.92%) COX8A;NDUFB6;ATP5F1D;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H