General Information of Drug (ID: DMZKPSQ)

Drug Name
Y-26763 Drug Info
Synonyms 127408-31-5
Cross-matching ID
PubChem CID
121878
ChEBI ID
CHEMBL92788
CAS Number
CAS 127408-31-5
TTD Drug ID
D05GPX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 1.81 7.01e-2 93/133 (69.92%) ATP5MC3;NDUFAB1;ATP5F1C;...
Vibrio cholerae infection 1.74 1.10e-1 44/50 (88%) ACTB;KCNQ1;ATP6V0C;...
Ribosome 1.62 2.72e-1 113/158 (71.52%) RPL26L1;RPL26;RPS5;...
Fc gamma R-mediated phagocytosis 1.58 3.24e-1 79/97 (81.44%) CDC42;BIN1;LYN;...
Metabolism of xenobiotics by cytochrome P450 1.57 2.80e-1 49/77 (63.64%) CYP1B1;UGT2B28;ALDH3A1;...
Proteasome 1.54 2.80e-1 44/46 (95.65%) PSMA6;PSMB4;PSMD14;...
Nucleotide excision repair 1.54 2.42e-1 40/47 (85.11%) CETN2;RPA3;RFC3;...
Mismatch repair 1.53 2.39e-1 22/23 (95.65%) RPA3;RFC3;RFC4;...
DNA replication 1.52 2.31e-1 34/36 (94.44%) RPA3;RFC3;POLE3;...
Cell cycle 1.51 2.34e-1 110/124 (88.71%) MAD2L1;TFDP2;PTTG1;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.48 2.76e-1 9/11 (81.82%) NQO1;COQ7;HPD;...
Thiamine metabolism 1.48 2.56e-1 12/15 (80%) AK4;TPK1;AK1
Leukocyte transendothelial migration 1.47 2.52e-1 90/114 (78.95%) CDC42;CTNNB1;CD99;...
Basal transcription factors 1.47 2.48e-1 37/45 (82.22%) TBPL1;TAF9B;GTF2A2;...
Pentose phosphate pathway 1.43 3.19e-1 25/30 (83.33%) PFKL;G6PD;PRPS2;...
Neutrophil extracellular trap formation 1.42 3.30e-1 101/189 (53.44%) HAT1;MPO;ACTB;...
Pentose and glucuronate interconversions 1.41 3.51e-1 17/34 (50%) SORD;UGT2B28;CRYL1;...
Huntington disease 1.40 3.45e-1 233/306 (76.14%) ITPR1;ATP5MC3;PSMA6;...
Primary bile acid biosynthesis 1.40 3.37e-1 15/17 (88.24%) SLC27A5;CH25H;AMACR;...
Butanoate metabolism 1.39 3.37e-1 23/28 (82.14%) BDH1;ABAT;HMGCL;...
Fanconi anemia pathway 1.39 3.33e-1 36/54 (66.67%) HES1;RPA3;RMI1;...
Glutathione metabolism 1.37 3.57e-1 43/57 (75.44%) GSTO1;GSTP1;HPGDS;...
Parkinson disease 1.37 3.49e-1 176/249 (70.68%) ITPR1;ATP5MC3;PSMA6;...
Peroxisome 1.37 3.37e-1 72/82 (87.8%) PHYH;PEX3;PEX11A;...
Spliceosome 1.35 3.65e-1 101/150 (67.33%) BUD31;PUF60;LSM5;...
Tight junction 1.34 3.76e-1 130/169 (76.92%) CDC42;CLDN8;CLDN10;...
Retrograde endocannabinoid signaling 1.30 3.98e-1 118/148 (79.73%) ITPR1;GNG7;NDUFAB1;...
Synthesis and degradation of ketone bodies 1.29 4.01e-1 9/10 (90%) BDH1;HMGCL;HMGCS2
Phagosome 1.29 3.97e-1 118/152 (77.63%) MPO;CORO1A;ACTB;...
Epithelial cell signaling in Helicobacter pylori infect... 1.29 3.87e-1 62/70 (88.57%) CDC42;LYN;ATP6V0C;...
Longevity regulating pathway -1.31 4.06e-1 90/151 (59.6%) CAMKK2;RB1CC1;PIK3R2;...
Glycosaminoglycan biosynthesis -1.31 4.02e-1 40/58 (68.97%) DSE;CSGALNACT2;B4GALT2;...
Human papillomavirus infection -1.32 4.11e-1 284/331 (85.8%) IFNAR2;PPP2R5A;ITGB5;...
Staphylococcus aureus infection -1.33 3.98e-1 72/95 (75.79%) HLA-DOB;C3;CFH;...
Riboflavin metabolism -1.34 4.06e-1 7/8 (87.5%) ACP2;ENPP1
Viral myocarditis -1.34 4.01e-1 53/60 (88.33%) HLA-DOB;CXADR;CASP3;...
Mannose type O-glycan biosynthesis -1.35 3.98e-1 14/23 (60.87%) LARGE1;POMT2;POMT1;...
Breast cancer -1.35 4.10e-1 119/147 (80.95%) IGF1;TCF7L2;FGF21;...
HIF-1 signaling pathway -1.37 4.09e-1 105/109 (96.33%) CAMK2B;LTBR;PFKFB3;...
Amoebiasis -1.38 3.92e-1 99/102 (97.06%) PLCB1;LAMA4;IFNG;...
Small cell lung cancer -1.40 3.47e-1 90/92 (97.83%) RXRB;BCL2L1;BIRC2;...
Dilated cardiomyopathy -1.42 3.20e-1 86/96 (89.58%) AGT;TPM1;TTN;...
Gastric cancer -1.43 3.31e-1 122/149 (81.88%) RXRB;ARAF;TGFB3;...
PI3K-Akt signaling pathway -1.47 2.52e-1 317/354 (89.55%) BCL2L1;IFNAR2;EIF4B;...
Ascorbate and aldarate metabolism -1.48 2.59e-1 15/30 (50%) UGT2B15;UGT2A3;ALDH2;...
Arrhythmogenic right ventricular cardiomyopathy -1.49 2.62e-1 70/77 (90.91%) TCF7L2;ACTN3;CACNA1F;...
Adipocytokine signaling pathway -1.49 2.71e-1 64/69 (92.75%) TNF;RXRG;JAK2;...
Type II diabetes mellitus -1.51 2.36e-1 42/46 (91.3%) SOCS1;TNF;CACNA1G;...
MicroRNAs in cancer -1.54 1.98e-1 146/310 (47.1%) RDX;CREBBP;CRKL;...
Calcium signaling pathway -1.54 2.16e-1 213/240 (88.75%) EGFR;ADCY3;FGF9;...
Malaria -1.58 1.70e-1 44/50 (88%) KLRK1;TGFB3;TNF;...
Glycerolipid metabolism -1.59 1.82e-1 44/61 (72.13%) MBOAT2;LPIN2;ALDH3A2;...
Focal adhesion -1.61 1.72e-1 180/201 (89.55%) THBS4;FLNC;ITGA2;...
Proteoglycans in cancer -1.62 1.81e-1 172/205 (83.9%) CAMK2B;EIF4B;ARAF;...
Fatty acid degradation -1.66 1.43e-1 40/43 (93.02%) ACSL5;ACAA2;ALDH2;...
PPAR signaling pathway -1.69 1.16e-1 66/74 (89.19%) RXRG;CYP7A1;SCD;...
Legionellosis -1.72 1.17e-1 51/57 (89.47%) PYCARD;NAIP;HSF1;...
Estrogen signaling pathway -1.76 1.18e-1 119/137 (86.86%) CALML3;AKT1;ADCY9;...
Regulation of lipolysis in adipocytes -1.79 1.20e-1 52/55 (94.55%) AKT1;ADCY9;ADRB2;...
ECM-receptor interaction -1.87 1.03e-1 80/88 (90.91%) THBS4;ITGA2;COMP;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H