Details of the Drug Pharmacogenomic Perturbation Atlas

[3H]CGP12177 Drug Info

4-(3-Tert-Butylamino-2-hydroxypropoxy)benzimidazol-2-one; Tbhpbo; 81047-99-6; 4-(3-tert-Butylamino-2-hydroxypropoxy)benzimidazol-2-one; CHEBI:73288; C14H19N3O3; 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one; 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one; 2H-Benzimidazol-2-one, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-1,3-dihydro-; (+/-)-CGP-12177A hydrochloride; Spectrum_001907; SpecPlus_000776; Spectrum4_000777; AC1Q6M3F

Cross-matching ID

PubChem CID

2687

ChEBI ID

CHEMBL73288

CAS Number

CAS 81047-99-6

TTD Drug ID

D03BZW

General Information of Drug (ID: DMZN1A3)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Dilated cardiomyopathy	2.20	0.00e+0	86/96 (89.58%)	DES;TGFB1;TTN;...
Hypertrophic cardiomyopathy	1.93	3.92e-2	81/90 (90%)	DES;TGFB1;TTN;...
Glycine, serine and threonine metabolism	-1.63	3.48e-2	31/40 (77.5%)	BHMT;GATM;GRHPR;...
Sulfur metabolism	-1.66	2.99e-2	9/10 (90%)	BPNT1;TST;SQOR;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.70	2.28e-2	62/70 (88.57%)	PLCG2;F11R;JUN;...
Metabolism of xenobiotics by cytochrome P450	-1.72	2.17e-2	49/77 (63.64%)	GSTA4;CYP3A5;ADH1C;...
Ascorbate and aldarate metabolism	-1.73	2.17e-2	15/30 (50%)	UGT2A3;AKR1A1;UGT2B4;...
Folate biosynthesis	-1.75	1.58e-2	23/26 (88.46%)	PCBD1;MOCS1;PAH;...
Nitrogen metabolism	-1.81	1.30e-2	16/17 (94.12%)	CA5B;CA6;CPS1;...
Tyrosine metabolism	-1.82	1.37e-2	30/36 (83.33%)	ADH6;GSTZ1;TYRP1;...
Collecting duct acid secretion	-1.86	5.43e-3	22/27 (81.48%)	SLC4A1;ATP6V1D;ATP6V1A;...
Steroid hormone biosynthesis	-1.87	6.21e-3	43/61 (70.49%)	AKR1C1;CYP7B1;HSD3B1;...
Complement and coagulation cascades	-1.96	3.62e-3	76/85 (89.41%)	SERPINB2;CPB2;F13B;...
Drug metabolism	-2.06	1.45e-3	78/151 (51.66%)	TK1;ADH6;IMPDH2;...
Ribosome	-2.16	0.00e+0	113/158 (71.52%)	MRPS2;RPL5;RPS21;...
Retinol metabolism	-2.23	0.00e+0	41/68 (60.29%)	AOX1;CYP3A7;CYP1A1;...
Mineral absorption	-2.29	0.00e+0	48/60 (80%)	SLC30A1;STEAP1;ATP1B3;...
Porphyrin and chlorophyll metabolism	-2.30	0.00e+0	23/43 (53.49%)	HCCS;FECH;ALAS2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H

VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H