Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZNFPG)

Drug Name
Terguride Drug Info
Synonyms
terguride; Dironyl; 37686-84-3; trans-Dihydrolisuride; (+)-Terguride; (5R,8S,10R)-Terguride; S(+)-Terguride; UNII-21OJT43Q88; TDHL; Transdihydrolisuride; (+)-(5R,8S,10R)-Terguride; CHEMBL73151; MLS000069833; Terguride [INN]; 21OJT43Q88; Terguridum [Latin]; Tergurida [Spanish]; SMR000058934; 9,10-alpha-Dihydrolisuride; 1,1-diethyl-3-(6-methyl-8alpha-ergolinyl)urea; Terguridum; Tergurida; Tergurid; EINECS 253-624-2; BRN 0766582; ZK 31224; trans-Dihydro Lisuride; 6-Methyl-8alpha-(diethylcarbamoylamino)ergoline
Cross-matching ID
PubChem CID
443951
ChEBI ID
CHEMBL73151
CAS Number
CAS 37686-84-3
TTD Drug ID
D01ZOB
INTEDE Drug ID
DR1559

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Human papillomavirus infection -1.67 4.99e-2 284/331 (85.8%) TNFRSF1A;PIK3R3;LAMA2;...
Ether lipid metabolism -1.68 4.96e-2 32/49 (65.31%) PAFAH2;PLA2G10;PLA2G5;...
Parathyroid hormone synthesis, secretion and action -1.70 4.97e-2 98/106 (92.45%) MEF2D;CREB3L1;MEF2C;...
Ovarian steroidogenesis -1.74 4.41e-2 41/51 (80.39%) SCARB1;LDLR;PRKACA;...
Necroptosis -1.74 4.43e-2 113/159 (71.07%) TLR3;GLUD2;IFNA17;...
Leishmaniasis -1.75 4.31e-2 67/77 (87.01%) HLA-DRA;IRAK1;HLA-DQA1;...
One carbon pool by folate -1.76 4.02e-2 15/20 (75%) MTHFD2;GART;DHFR;...
Focal adhesion -1.82 2.96e-2 180/201 (89.55%) SOS2;RAPGEF1;AKT1;...
ECM-receptor interaction -1.82 3.18e-2 80/88 (90.91%) ITGB8;GP9;LAMC3;...
PI3K-Akt signaling pathway -1.87 2.78e-2 317/354 (89.55%) GRB2;FGF20;ITGA2;...
Coronavirus disease -1.89 2.51e-2 215/232 (92.67%) FOS;TNFRSF1A;ADAM17;...
Hepatitis C -2.04 3.48e-3 139/157 (88.54%) GRB2;TLR3;MYC;...
Measles -2.07 4.64e-3 133/139 (95.68%) FOS;PIK3R3;TLR7;...
Influenza A -2.12 6.96e-3 156/172 (90.7%) NXT2;HLA-DPA1;SOCS3;...
Herpes simplex virus 1 infection -2.13 1.39e-2 165/498 (33.13%) HLA-DPA1;SOCS3;FAS;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H