General Information of Drug (ID: DMZNPMQ)

Drug Name
2-(4-methoxybenzylthio)-6-methylpyrimidin-4-ol Drug Info
Cross-matching ID
PubChem CID
716696
TTD Drug ID
D05DBJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Cell cycle 1.73 3.11e-1 110/124 (88.71%) PLK1;CDKN1B;CDC20;...
Carbohydrate digestion and absorption 1.67 3.29e-1 37/47 (78.72%) SLC37A4;MGAM;PLCB1;...
Propanoate metabolism 1.57 4.85e-1 30/34 (88.24%) SUCLA2;ABAT;DLD;...
Homologous recombination 1.57 3.64e-1 35/41 (85.37%) BRCA1;RPA3;MRE11;...
Fanconi anemia pathway 1.57 2.98e-1 36/54 (66.67%) BRCA1;RPA3;RAD51C;...
Butanoate metabolism 1.56 2.59e-1 23/28 (82.14%) BDH2;ABAT;ACAT1;...
Diabetic cardiomyopathy 1.54 2.88e-1 162/203 (79.8%) MMP9;PLCB1;PIK3R1;...
Glyoxylate and dicarboxylate metabolism 1.51 3.21e-1 23/30 (76.67%) DLD;ACAT1;GLDC;...
DNA replication 1.49 3.45e-1 34/36 (94.44%) PRIM1;RPA3;POLE2;...
Aminoacyl-tRNA biosynthesis 1.49 3.20e-1 15/66 (22.73%) IARS2;QRSL1;FARS2;...
Sulfur relay system 1.47 3.30e-1 5/8 (62.5%) TST;MPST;MOCS2;...
Progesterone-mediated oocyte maturation 1.46 3.21e-1 75/100 (75%) PLK1;MAD2L1;PIK3R1;...
Fc epsilon RI signaling pathway 1.45 3.10e-1 57/68 (83.82%) ALOX5;PIK3R1;MAPK1;...
Fatty acid elongation 1.44 3.21e-1 19/27 (70.37%) ACAA2;PPT1;TECR;...
Leukocyte transendothelial migration 1.42 3.37e-1 90/114 (78.95%) MMP9;MYL12B;PIK3R1;...
Synthesis and degradation of ketone bodies 1.42 3.17e-1 9/10 (90%) BDH2;ACAT1;OXCT1
SNARE interactions in vesicular transport 1.40 3.45e-1 19/33 (57.58%) BET1;STX8;STX3;...
Glutamatergic synapse 1.39 3.49e-1 97/114 (85.09%) GRIA2;PLCB1;GRIK2;...
Renin-angiotensin system 1.39 3.36e-1 20/23 (86.96%) ANPEP;MME;REN;...
Neutrophil extracellular trap formation 1.39 3.37e-1 101/189 (53.44%) PLCB1;PIK3R1;HAT1;...
Oocyte meiosis 1.38 3.55e-1 90/129 (69.77%) PLK1;CDC20;MAD2L1;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1.37 3.51e-1 20/26 (76.92%) PIGC;PIGP;GPAA1;...
Transcriptional misregulation in cancer 1.36 3.50e-1 158/192 (82.29%) CDKN1B;DEFA4;MMP9;...
Retrograde endocannabinoid signaling 1.35 3.65e-1 118/148 (79.73%) GRIA2;PLCB1;NDUFA5;...
TGF-beta signaling pathway 1.35 3.62e-1 81/94 (86.17%) ID4;HAMP;IFNG;...
Oxidative phosphorylation 1.34 3.71e-1 93/133 (69.92%) NDUFA5;NDUFB3;SDHC;...
Serotonergic synapse 1.32 4.00e-1 97/114 (85.09%) ALOX5;PLCB1;MAPK1;...
GnRH secretion 1.29 4.68e-1 60/64 (93.75%) PLCB1;PIK3R1;MAPK1;...
Long-term depression 1.28 4.79e-1 55/60 (91.67%) GRIA2;PLCB1;MAPK1;...
Taurine and hypotaurine metabolism 1.28 4.67e-1 8/11 (72.73%) ADO;GAD1;CSAD;...
beta-Alanine metabolism -1.41 2.29e-1 25/30 (83.33%) ALDH3B1;AOC2;ALDH9A1;...
Nitrogen metabolism -1.43 1.96e-1 16/17 (94.12%) GLUL;CA4;CA9;...
alpha-Linolenic acid metabolism -1.43 1.91e-1 17/25 (68%) PLA2G10;PLA2G2D;ACAA1;...
Herpes simplex virus 1 infection -1.45 1.77e-1 165/498 (33.13%) HCFC2;DDX58;MTOR;...
Endocytosis -1.46 1.70e-1 198/252 (78.57%) HGS;ARFGAP2;ACAP2;...
Thyroid hormone synthesis -1.46 1.70e-1 66/75 (88%) PLCB4;CREB3;ALB;...
Amino sugar and nucleotide sugar metabolism -1.47 1.61e-1 38/48 (79.17%) NANS;GFPT2;GMDS;...
Bacterial invasion of epithelial cells -1.48 1.64e-1 59/77 (76.62%) SHC1;DOCK1;DNM1;...
Autophagy -1.48 1.56e-1 113/169 (66.86%) DAPK3;HRAS;MTMR4;...
Allograft rejection -1.49 1.58e-1 32/38 (84.21%) HLA-DOB;HLA-F;HLA-E;...
Antigen processing and presentation -1.49 1.60e-1 60/78 (76.92%) CTSL;NFYA;CANX;...
Phenylalanine metabolism -1.50 1.53e-1 14/17 (82.35%) HPD;ALDH3B1;AOC2;...
Phagosome -1.50 1.60e-1 118/152 (77.63%) SEC61G;ATP6V0A4;CTSL;...
Arachidonic acid metabolism -1.51 1.61e-1 48/61 (78.69%) PTGDS;PTGES3;PLA2G10;...
Ascorbate and aldarate metabolism -1.52 1.59e-1 15/30 (50%) ALDH2;UGDH;ALDH3A2
Vibrio cholerae infection -1.52 1.66e-1 44/50 (88%) PLCG2;KDELR3;ACTB;...
ECM-receptor interaction -1.52 1.64e-1 80/88 (90.91%) ITGB6;COL4A6;LAMC3;...
Epithelial cell signaling in Helicobacter pylori infect... -1.54 1.53e-1 62/70 (88.57%) CCL5;PLCG2;PAK1;...
Viral myocarditis -1.54 1.60e-1 53/60 (88.33%) CYCS;CASP9;RAC3;...
Mitophagy -1.54 1.72e-1 56/68 (82.35%) CSNK2B;MAPK9;USP8;...
Graft-versus-host disease -1.55 1.83e-1 32/42 (76.19%) HLA-DOB;HLA-F;HLA-E;...
Histidine metabolism -1.57 1.61e-1 16/22 (72.73%) MAOA;ALDH2;ALDH3A2;...
Ferroptosis -1.58 1.61e-1 36/41 (87.8%) GCLC;TP53;FTL;...
Basal cell carcinoma -1.60 1.65e-1 41/63 (65.08%) TCF7L1;TCF7;FZD7;...
Viral protein interaction with cytokine and cytokine re... -1.60 1.85e-1 84/100 (84%) CXCL13;IL2RG;CCL17;...
Autoimmune thyroid disease -1.62 1.69e-1 46/53 (86.79%) TSHR;HLA-DOB;TPO;...
Glutathione metabolism -1.63 1.81e-1 43/57 (75.44%) GCLC;ODC1;IDH1;...
Protein export -1.67 1.58e-1 17/23 (73.91%) SRPRB;SEC61G;SRP14;...
Protein processing in endoplasmic reticulum -1.67 1.82e-1 127/171 (74.27%) GANAB;MOGS;SEC61G;...
Collecting duct acid secretion -1.74 1.68e-1 22/27 (81.48%) ATP6V0A4;SLC4A1;ATP6V0E2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H