Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZO6CV)

• Drug Name: tiratricol Drug Info
• Synonyms: TRIAC; 3,3',5-triiodothyroacetic acid
• Cross-matching ID:
  PubChem CID: 5803
  ChEBI ID: CHEMBL41632
  CAS Number: CAS 51-24-1
  TTD Drug ID: D0J6XC

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.12	0.00e+0	76/85 (89.41%)	C3;SERPINA1;CFI;...
Staphylococcus aureus infection	2.09	0.00e+0	72/95 (75.79%)	HLA-DQA1;C3;CFI;...
Valine, leucine and isoleucine degradation	2.02	0.00e+0	42/48 (87.5%)	DLD;AOX1;HMGCS2;...
Systemic lupus erythematosus	2.00	0.00e+0	45/135 (33.33%)	HLA-DQA1;C3;HLA-DPA1;...
Propanoate metabolism	1.97	0.00e+0	30/34 (88.24%)	DLD;ACOX1;LDHB;...
Antigen processing and presentation	1.84	1.12e-2	60/78 (76.92%)	HLA-DQA1;HLA-DPA1;HSPA2;...
Leishmaniasis	1.80	2.05e-2	67/77 (87.01%)	HLA-DQA1;C3;HLA-DPA1;...
Type I diabetes mellitus	1.77	2.39e-2	38/43 (88.37%)	HLA-DQA1;HLA-DPA1;PRF1;...
Retinol metabolism	1.72	3.83e-2	41/68 (60.29%)	AOX1;CYP3A5;UGT2B15;...
Pyruvate metabolism	1.72	3.44e-2	41/47 (87.23%)	ME2;DLD;LDHB;...
Fatty acid degradation	1.72	3.39e-2	40/43 (93.02%)	ACOX1;HADHB;ADH1A;...
Glyoxylate and dicarboxylate metabolism	1.71	3.19e-2	23/30 (76.67%)	DLD;SHMT1;GLUL;...
One carbon pool by folate	1.71	2.94e-2	15/20 (75%)	SHMT1;ALDH1L1;MTR;...
Pentose and glucuronate interconversions	1.66	4.91e-2	17/34 (50%)	UGT2B15;UGT2B28;SORD;...
Mineral absorption	-1.90	3.19e-2	48/60 (80%)	HEPH;SLC26A6;CYBRD1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	3.33uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	24H	Show ▼