Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZP7YM)

Drug Name
L-165041 Drug Info
Synonyms L165041
Cross-matching ID
PubChem CID
6603901
ChEBI ID
CHEMBL153057
CAS Number
CAS 79558-09-1
TTD Drug ID
D0YK9T

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycosaminoglycan degradation -1.69 4.20e-2 19/19 (100%) ARSB;HYAL2;IDUA;...
Vibrio cholerae infection -1.70 4.58e-2 44/50 (88%) ATP6V1D;ATP6V0E1;PRKACB;...
Primary immunodeficiency -1.80 1.69e-2 33/38 (86.84%) ZAP70;LCK;CD79A;...
Biosynthesis of unsaturated fatty acids -1.83 9.38e-3 21/27 (77.78%) ELOVL5;FADS1;ACOX3;...
Lysosome -1.85 9.77e-3 115/128 (89.84%) CTSW;M6PR;NAGPA;...
Ether lipid metabolism -1.88 5.21e-3 32/49 (65.31%) PLPP1;PLA2G6;PLA2G1B;...
Mitophagy -1.93 3.91e-3 56/68 (82.35%) RRAS2;RAB7A;TFEB;...
Sphingolipid metabolism -1.94 7.81e-3 32/49 (65.31%) DEGS1;SPHK1;CERS6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H