Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMZSOG2)

Drug Name
STO609 Drug Info
Synonyms STO-609; STO 609
Cross-matching ID
PubChem CID
3467590
ChEBI ID
CHEMBL1182777
TTD Drug ID
D0HZ8U

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.11 0.00e+0 84/94 (89.36%) LCN2;CXCL8;CXCL5;...
NF-kappa B signaling pathway 1.89 1.27e-2 90/104 (86.54%) CXCL8;CXCL1;RELB;...
Malaria 1.80 4.04e-2 44/50 (88%) CXCL8;ITGB2;IL1B;...
Histidine metabolism 1.79 3.19e-2 16/22 (72.73%) ALDH2;ALDH3A1;ALDH3B1;...
Vitamin digestion and absorption -1.84 4.27e-2 17/24 (70.83%) APOA4;SLC19A3;ABCC1;...
Steroid hormone biosynthesis -1.85 4.82e-2 43/61 (70.49%) CYP7A1;CYP17A1;CYP3A4;...
Pentose and glucuronate interconversions -1.88 4.60e-2 17/34 (50%) CRYL1;UGT2B17;UGT2B4;...
Protein digestion and absorption -2.03 0.00e+0 78/103 (75.73%) COL13A1;CPA1;PRSS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 12.5uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H